The effect of donor alcohol abuse on outcomes following heart transplantation

Joshua Newman, Max Liebo, Brian D. Lowes, Haseeb Ilias Basha, Yael Peled, Emily Cendrowski, Ronald Zolty, Dylan Douglas, John Y. Um, Edwin McGee, Alain Heroux, Eugenia Raichlin

Research output: Contribution to journalArticle

Abstract

Background: Current guidelines recommend against the use of hearts from donors that abuse alcohol. We explored the effect of donor alcohol abuse (AA) on cardiac allograft function and outcomes in heart transplant (HTx) recipients. Methods: Overall, 370 HTx recipients were divided into two groups: (a) the alcoholic donor group (AD, n = 58) and (b) the non-alcoholic donor group (NAD, n = 312). Results: Recipients in the AD group had a slower heart rate (86 ± 13 vs 93 ± 13, P = 0.004) and an increased incidence of early atrial fibrillation (AF) (30% vs 11%, P = 0.003). Echocardiographic left ventricular mass was higher among alcoholic donors (171.7 ± 66.7 vs 151.6 ± 54.7, P = 0.02). This difference remained present 1 year following HTx (185 ± 43 vs 166 ± 42, P = 0.007). E/E′ was higher in the AD group (9.5 ± 3.9 vs 8.4 ± 2.9, P = 0.04) and a larger number of AD recipients had a ventilatory equivalent for VCO 2 > 34 (50% vs 31%, P = 0.04) on cardiopulmonary exercise test. There was no significant difference in rejection, cardiac allograft vasculopathy (CAV), or survival between the groups. Conclusions: Our data suggest that donor AA does not impact rejection, CAV, or intermediate-term survival, but may cause increased incidence of post-HTx AF and impaired cardiac allograft diastolic function.

Original languageEnglish (US)
Article numbere13461
JournalClinical Transplantation
Volume33
Issue number2
DOIs
StatePublished - Feb 1 2019

Keywords

  • atrial fibrillation
  • diastolic dysfunction
  • donor characteristics
  • heart transplantation

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'The effect of donor alcohol abuse on outcomes following heart transplantation'. Together they form a unique fingerprint.

  • Cite this

    Newman, J., Liebo, M., Lowes, B. D., Ilias Basha, H., Peled, Y., Cendrowski, E., Zolty, R., Douglas, D., Um, J. Y., McGee, E., Heroux, A., & Raichlin, E. (2019). The effect of donor alcohol abuse on outcomes following heart transplantation. Clinical Transplantation, 33(2), [e13461]. https://doi.org/10.1111/ctr.13461