The rise of e-commerce in emerging economies has presented a number of opportunities for micro-enterprises which include access to information and expertise, competitiveness and access to markets, administrative efficiencies, and productivity through learning about innovations. The occurrences of these factors suggest a rise in income and reduction in poverty. However, there are certain challenges that need to be overcome before the promise of e-commerce can be reached. This paper addresses the challenges in achieving the benefits of e-commerce. Following an analysis of the effects of e-commerce on development, this paper provides a framework for evaluating the factors that effect e-commerce in micro-enterprises. The expected contribution of this research is in formulating a lens through which micro-enterprises may implement e-commerce into their business processes.