The effect of human chorionic gonadotropin (HCG) on functional recovery of spinal cord sectioned rats

A. A. Patil, M. P. Nagaraj

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The effect of human chorionic gonadotropin (HCG) on functional recovery after complete spinal cord transection in the rat was studied. Twelve rats (6 male and 6 female) received HCG daily for the first week and then every alternate day for three weeks. Ten rats (5 male and 5 female) served as controls. Return of bladder function, Tarlov's grading and measuring the maximum angle at which the rats were able to climb up an inclined plane were used as criteria in assessing the functional recovery. Improvement was noted in the HCG-treated rats by the end of two weeks. At six weeks the recovery of HCG-treated rats as compared to the control group was very significant (p < 0.001). No recovery whatsoever was noted in the control group even after six weeks. Histological evidence of bridging of the gap between the cut ends of the spinal cord by nerve fibres containing tissue was noted in the HCG-treated rats only. The possible mode of action of HCG on spinal cord injury is briefly discussed.

Original languageEnglish (US)
Pages (from-to)205-218
Number of pages14
JournalActa Neurochirurgica
Volume69
Issue number3-4
DOIs
StatePublished - Sep 1983

Keywords

  • Spinal cord injury
  • human chorionic gonadotropin
  • nerve fibre regeneration

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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