The effect of intermittent IL-2 therapy on CD4 T cells in the gut in HIV-1-infected patients

Sarah W. Read, Emily J. Ciccone, Peter J. Mannon, Michael D. Yao, Cheryl L. Chairez, Richard T. Davey, Joseph A. Kovacs, Irini Sereti

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We sought to determine the effects of interleukin-2 administered in combination with antiretroviral therapy (ART) on CD4+ T cells in the gut. Lymphocytes from whole blood, colon, and terminal ileum of HIV-infected adults treated with interleukin-2 and ART or ART alone were examined. There were no differences between groups in the proportion of CD4+ T cells or in expression of CD25 or Ki67 by CD4 T cells in the gut. Although IL-2 administration leads to expansion of peripheral blood CD4+ T cells, there is no alteration in the proportion or activation of CD4 T cells in the gut mucosa.

Original languageEnglish (US)
Pages (from-to)340-343
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume56
Issue number4
DOIs
StatePublished - Apr 1 2011
Externally publishedYes

Keywords

  • CD4
  • HIV
  • IL-2
  • gastrointestinal tract
  • mucosa

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'The effect of intermittent IL-2 therapy on CD4 T cells in the gut in HIV-1-infected patients'. Together they form a unique fingerprint.

Cite this