Abstract
We sought to determine the effects of interleukin-2 administered in combination with antiretroviral therapy (ART) on CD4+ T cells in the gut. Lymphocytes from whole blood, colon, and terminal ileum of HIV-infected adults treated with interleukin-2 and ART or ART alone were examined. There were no differences between groups in the proportion of CD4+ T cells or in expression of CD25 or Ki67 by CD4 T cells in the gut. Although IL-2 administration leads to expansion of peripheral blood CD4+ T cells, there is no alteration in the proportion or activation of CD4 T cells in the gut mucosa.
Original language | English (US) |
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Pages (from-to) | 340-343 |
Number of pages | 4 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 56 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2011 |
Externally published | Yes |
Keywords
- CD4
- HIV
- IL-2
- gastrointestinal tract
- mucosa
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)