The effect of myc proteins on SV40 replication in human lymphoid cells

M. Classon, M. Henriksson, G. Klein, J. Sumegi

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We have previously demonstrated that over-expression of c-myc facilitates the replication of SV40 DNA in human Burkitt lymphoma cells (BL). In this paper we investigated the ability of N-myc and L-myc to substitute for c-myc in promoting SV40 DNA replication. Vectors expressing either a chimeric N-myc/c-myc, N-myc or L-myc gene were constructed and co-transfected with a plasmid containing the SV40 origin of replication and the early genes encoding SV40 T antigens (Tag). The chimeric N-myc/c-myc and the N-myc proteins enhance SV40 replication in the human lymphoma line BJAB at levels comparable to c-myc. The stimulative effect of N-myc is also evident in the BL cell line RAMOS. However, L-myc stimulated SV40 replication only in RAMOS cells.

Original languageEnglish (US)
Pages (from-to)1371-1376
Number of pages6
JournalOncogene
Volume5
Issue number9
StatePublished - 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Classon, M., Henriksson, M., Klein, G., & Sumegi, J. (1990). The effect of myc proteins on SV40 replication in human lymphoid cells. Oncogene, 5(9), 1371-1376.