TY - JOUR
T1 - The effect of sodium thiosulfate administration on nephrocalcinosis in a rat model
AU - Lagrange, Chad A.
AU - Lele, Subodh M.
AU - Pais, Vernon M.
PY - 2009/3/1
Y1 - 2009/3/1
N2 - Introduction: Sodium thiosulfate (STS) is a U.S. Food and Drug Administration (FDA)-approved chelating agent that is used for the treatment of cyanide poisoning and prophylaxis against cisplatin nephropathy. Recently, STS has also been used in the treatment of calciphylaxis, which is a disease characterized by calcification in the soft tissues with vascular calcification and thrombosis causing nonhealing ulcers. We proposed a rat model to evaluate whether STS has any possible beneficial effect on calcium nephrolithiasis or nephrocalcinosis. Methods: Twenty-one male Sprague-Dawley rats were used in the study. All animals received standard rat chow throughout the experiment. The animals were started on special drinking water containing 0.4% ethylene glycol plus 1.0% ammonium chloride for 7 days to induce crystalluria and nephrocalcinosis. The animals were then randomized to two groups. Group 1 served as a control and received daily intraperitoneal injections of normal saline. Group 2 received daily intraperitoneal injections of STS solution. Special drinking water containing 0.8% ethylene glycol was continued during the treatment period. Results: Group 2 gained significantly less weight than group 1 (18.0% v 8.5%, p< 0.05). The amount of crystalluria in group 2 was much less than that in group 1, but did not reach statistical significance (0.7 v 4.2, p= 0.09). Degree of calcification noted in the kidneys was not statistically different between the two groups. Conclusions: The current study did not reveal any significant benefit of STS administration on calcium stone disease. However, many more studies are necessary before the possibility of a beneficial effect is completely disproved.
AB - Introduction: Sodium thiosulfate (STS) is a U.S. Food and Drug Administration (FDA)-approved chelating agent that is used for the treatment of cyanide poisoning and prophylaxis against cisplatin nephropathy. Recently, STS has also been used in the treatment of calciphylaxis, which is a disease characterized by calcification in the soft tissues with vascular calcification and thrombosis causing nonhealing ulcers. We proposed a rat model to evaluate whether STS has any possible beneficial effect on calcium nephrolithiasis or nephrocalcinosis. Methods: Twenty-one male Sprague-Dawley rats were used in the study. All animals received standard rat chow throughout the experiment. The animals were started on special drinking water containing 0.4% ethylene glycol plus 1.0% ammonium chloride for 7 days to induce crystalluria and nephrocalcinosis. The animals were then randomized to two groups. Group 1 served as a control and received daily intraperitoneal injections of normal saline. Group 2 received daily intraperitoneal injections of STS solution. Special drinking water containing 0.8% ethylene glycol was continued during the treatment period. Results: Group 2 gained significantly less weight than group 1 (18.0% v 8.5%, p< 0.05). The amount of crystalluria in group 2 was much less than that in group 1, but did not reach statistical significance (0.7 v 4.2, p= 0.09). Degree of calcification noted in the kidneys was not statistically different between the two groups. Conclusions: The current study did not reveal any significant benefit of STS administration on calcium stone disease. However, many more studies are necessary before the possibility of a beneficial effect is completely disproved.
UR - http://www.scopus.com/inward/record.url?scp=65549171030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65549171030&partnerID=8YFLogxK
U2 - 10.1089/end.2008.0204
DO - 10.1089/end.2008.0204
M3 - Article
C2 - 19193134
AN - SCOPUS:65549171030
SN - 0892-7790
VL - 23
SP - 529
EP - 533
JO - Journal of Endourology
JF - Journal of Endourology
IS - 3
ER -