The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils

H. Miyagawa; M. Nabe; R. J. Hopp; C. Okada; A. K. Bewtra; G. Townley

doi:10.1007/BF01987888

The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC₄ production from eosinophils

H. Miyagawa, M. Nabe, R. J. Hopp, C. Okada, A. K. Bewtra, G. Townley

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We investigated the effect of WEB 2086, a selective platelet-activating factor (PAF) receptor antagonist, on PAF-induced eosinophil chemotaxis and LTC₄ production. WEB 2086 inhibited PAF-induced eosinophil chemotaxis in normals and asthmatics. To further determine if WEB 2086 is a selective PAF receptor antagonist, we examined the effect of WEB 2086 against formyl-methionyl-leucyl-phenylalanine (fMLP)-induced or eosinophil chemotactic factor of anaphylaxis (ECF-A)-induced eosinophil chemotaxis. WEB 2086 did not have a significant inhibition against fMLP or ECF-A-induced eosinophil chemotaxis. These results suggest that WEB 2086 is a selective and potent inhibitor of PAF-induced eosinophil chemotaxis and LTC₄ production from eosinophils, due to its antagonism of PAF-receptors.

Original language	English (US)
Pages (from-to)	39-43
Number of pages	5
Journal	Agents and Actions
Volume	37
Issue number	1-2
DOIs	https://doi.org/10.1007/BF01987888
State	Published - Sep 1992
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Pharmacology (medical)

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10.1007/BF01987888

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title = "The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils",

abstract = "We investigated the effect of WEB 2086, a selective platelet-activating factor (PAF) receptor antagonist, on PAF-induced eosinophil chemotaxis and LTC4 production. WEB 2086 inhibited PAF-induced eosinophil chemotaxis in normals and asthmatics. To further determine if WEB 2086 is a selective PAF receptor antagonist, we examined the effect of WEB 2086 against formyl-methionyl-leucyl-phenylalanine (fMLP)-induced or eosinophil chemotactic factor of anaphylaxis (ECF-A)-induced eosinophil chemotaxis. WEB 2086 did not have a significant inhibition against fMLP or ECF-A-induced eosinophil chemotaxis. These results suggest that WEB 2086 is a selective and potent inhibitor of PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils, due to its antagonism of PAF-receptors.",

author = "H. Miyagawa and M. Nabe and Hopp, {R. J.} and C. Okada and Bewtra, {A. K.} and G. Townley",

year = "1992",

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T1 - The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils

AU - Miyagawa, H.

AU - Nabe, M.

AU - Hopp, R. J.

AU - Okada, C.

AU - Bewtra, A. K.

AU - Townley, G.

PY - 1992/9

Y1 - 1992/9

N2 - We investigated the effect of WEB 2086, a selective platelet-activating factor (PAF) receptor antagonist, on PAF-induced eosinophil chemotaxis and LTC4 production. WEB 2086 inhibited PAF-induced eosinophil chemotaxis in normals and asthmatics. To further determine if WEB 2086 is a selective PAF receptor antagonist, we examined the effect of WEB 2086 against formyl-methionyl-leucyl-phenylalanine (fMLP)-induced or eosinophil chemotactic factor of anaphylaxis (ECF-A)-induced eosinophil chemotaxis. WEB 2086 did not have a significant inhibition against fMLP or ECF-A-induced eosinophil chemotaxis. These results suggest that WEB 2086 is a selective and potent inhibitor of PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils, due to its antagonism of PAF-receptors.

AB - We investigated the effect of WEB 2086, a selective platelet-activating factor (PAF) receptor antagonist, on PAF-induced eosinophil chemotaxis and LTC4 production. WEB 2086 inhibited PAF-induced eosinophil chemotaxis in normals and asthmatics. To further determine if WEB 2086 is a selective PAF receptor antagonist, we examined the effect of WEB 2086 against formyl-methionyl-leucyl-phenylalanine (fMLP)-induced or eosinophil chemotactic factor of anaphylaxis (ECF-A)-induced eosinophil chemotaxis. WEB 2086 did not have a significant inhibition against fMLP or ECF-A-induced eosinophil chemotaxis. These results suggest that WEB 2086 is a selective and potent inhibitor of PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils, due to its antagonism of PAF-receptors.

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The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC₄ production from eosinophils

Abstract

ASJC Scopus subject areas

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