The effects of irradiation on the haematopoietic tissues of anaesthetized mice

A. C. Riche; J. G. Sharp; V. Littlewood; D. Thomas

doi:10.1159/000208329

The effects of irradiation on the haematopoietic tissues of anaesthetized mice

A. C. Riche, J. G. Sharp, V. Littlewood, D. Thomas

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Abstract

The effects of irradiation on the haematopoietic tissues of anaesthetized mice were measured using the balance between damage and recovery during the 10 day period following the administration of various doses of whole body X irradiation. The cellularity of the femoral bone marrow, the weight of the spleen and the number of (endogenous) spleen colonies are elevated in animals anaesthetized using Avertin during exposure to doses of whole body X irradiation in the range between 400 and 850 rad, with a dose reduction factor of 1.2 to 1.4.

Original language	English (US)
Pages (from-to)	50-55
Number of pages	6
Journal	Acta Haematologica
Volume	50
Issue number	1
DOIs	https://doi.org/10.1159/000208329
State	Published - 1973
Externally published	Yes

ASJC Scopus subject areas

Hematology

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10.1159/000208329

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title = "The effects of irradiation on the haematopoietic tissues of anaesthetized mice",

abstract = "The effects of irradiation on the haematopoietic tissues of anaesthetized mice were measured using the balance between damage and recovery during the 10 day period following the administration of various doses of whole body X irradiation. The cellularity of the femoral bone marrow, the weight of the spleen and the number of (endogenous) spleen colonies are elevated in animals anaesthetized using Avertin during exposure to doses of whole body X irradiation in the range between 400 and 850 rad, with a dose reduction factor of 1.2 to 1.4.",

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AU - Sharp, J. G.

AU - Littlewood, V.

AU - Thomas, D.

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AB - The effects of irradiation on the haematopoietic tissues of anaesthetized mice were measured using the balance between damage and recovery during the 10 day period following the administration of various doses of whole body X irradiation. The cellularity of the femoral bone marrow, the weight of the spleen and the number of (endogenous) spleen colonies are elevated in animals anaesthetized using Avertin during exposure to doses of whole body X irradiation in the range between 400 and 850 rad, with a dose reduction factor of 1.2 to 1.4.

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The effects of irradiation on the haematopoietic tissues of anaesthetized mice

Abstract

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