The effects of mustine hydrochloride on the colony forming units of murine bone marrow

J. G. Sharp, D. Brynmor Thomas

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The sequence of changes in the CFU content of murine bone marrow has been studied during the brief period of survival which follows the i.v. administration of a single lethal dose (100 μg) of mustine hydrochloride. Within 24 h a tenfold decrease in the number of CFU which can be aspirated from a single femoral diaphysis has been observed. This is followed by an increase which restores the CFU content of the femoral diaphysis to control values between the 4th and the 8th days after treatment.

Original languageEnglish (US)
Pages (from-to)271-274
Number of pages4
JournalActa Haematologica
Volume46
Issue number5
DOIs
StatePublished - 1971

Keywords

  • Colony forming units
  • Mouse bone marrow
  • Nitrogen mustard

ASJC Scopus subject areas

  • Hematology

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