The effects of mustine hydrochloride on the colony forming units of murine bone marrow

J. G. Sharp; D. Brynmor Thomas

doi:10.1159/000208586

The effects of mustine hydrochloride on the colony forming units of murine bone marrow

J. G. Sharp, D. Brynmor Thomas

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The sequence of changes in the CFU content of murine bone marrow has been studied during the brief period of survival which follows the i.v. administration of a single lethal dose (100 μg) of mustine hydrochloride. Within 24 h a tenfold decrease in the number of CFU which can be aspirated from a single femoral diaphysis has been observed. This is followed by an increase which restores the CFU content of the femoral diaphysis to control values between the 4th and the 8th days after treatment.

Original language	English (US)
Pages (from-to)	271-274
Number of pages	4
Journal	Acta Haematologica
Volume	46
Issue number	5
DOIs	https://doi.org/10.1159/000208586
State	Published - 1971
Externally published	Yes

Keywords

Colony forming units
Mouse bone marrow
Nitrogen mustard

ASJC Scopus subject areas

Hematology

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10.1159/000208586

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abstract = "The sequence of changes in the CFU content of murine bone marrow has been studied during the brief period of survival which follows the i.v. administration of a single lethal dose (100 μg) of mustine hydrochloride. Within 24 h a tenfold decrease in the number of CFU which can be aspirated from a single femoral diaphysis has been observed. This is followed by an increase which restores the CFU content of the femoral diaphysis to control values between the 4th and the 8th days after treatment.",

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AB - The sequence of changes in the CFU content of murine bone marrow has been studied during the brief period of survival which follows the i.v. administration of a single lethal dose (100 μg) of mustine hydrochloride. Within 24 h a tenfold decrease in the number of CFU which can be aspirated from a single femoral diaphysis has been observed. This is followed by an increase which restores the CFU content of the femoral diaphysis to control values between the 4th and the 8th days after treatment.

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KW - Nitrogen mustard

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The effects of mustine hydrochloride on the colony forming units of murine bone marrow

Abstract

Keywords

ASJC Scopus subject areas

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