The embryonic and post-natal expression of the nicotinic receptor α3-subunit in rat lower brainstem

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11 Scopus citations

Abstract

The mRNA expression of the α3 nicotinic acetylcholine receptor subunit in the rat lower brainstem is more widespread in the embryo and at birth than in the mature brain, but the major cell groups expressing α3 are generally the same, with two exceptions. The transcript for the α3-subunit is transiently expressed in the ventral cochlear nucleus (VCN). Expression was very high in the embryonic and early post-natal VCN, but was significantly decreased in the VCN late in the post-natal period (about post-natal day 15). Conversely, α3 mRNA was not expressed in the motor trigeminal nucleus until about PN3.

Original languageEnglish (US)
Pages (from-to)407-412
Number of pages6
JournalMolecular Brain Research
Volume48
Issue number2
DOIs
StatePublished - Sep 1997

Keywords

  • Development
  • Facial nucleus
  • Nicotinic acetylcholine receptor
  • Trigeminal nucleus
  • Ventral cochlear nucleus
  • α3-subunit

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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