The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

Hussin A. Rothan, Siddappa N. Byrareddy

Research output: Contribution to journalReview articlepeer-review

3468 Scopus citations


Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. Based on the large number of infected people that were exposed to the wet animal market in Wuhan City, China, it is suggested that this is likely the zoonotic origin of COVID-19. Person-to-person transmission of COVID-19 infection led to the isolation of patients that were subsequently administered a variety of treatments. Extensive measures to reduce person-to-person transmission of COVID-19 have been implemented to control the current outbreak. Special attention and efforts to protect or reduce transmission should be applied in susceptible populations including children, health care providers, and elderly people. In this review, we highlights the symptoms, epidemiology, transmission, pathogenesis, phylogenetic analysis and future directions to control the spread of this fatal disease.

Original languageEnglish (US)
Article number102433
JournalJournal of Autoimmunity
StatePublished - May 2020


  • COVID-19
  • Coronavirus
  • Pathogenesis
  • Pneumonia
  • Wuhan city

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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