The evolution of the antimicrobial peptide database over 18 years: Milestones and new features

Guangshun Wang, C. Michael Zietz, Ashok Mudgapalli, Shuona Wang, Zhe Wang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The antimicrobial peptide database (APD) has served the antimicrobial peptide field for 18 years. Because it is widely used in research and education, this article documents database milestones and key events that have transformed it into the current form. A comparison is made for the APD peptide statistics between 2010 and 2020, validating the major database findings to date. We also describe new additions ranging from peptide entries to search functions. Of note, the APD also contains antimicrobial peptides from host microbiota, which are important in shaping immune systems and could be linked to a variety of human diseases. Finally, the database has been re-programmed to the web branding and latest security compliance of the University of Nebraska Medical Center. The reprogrammed APD can be accessed at https://aps.unmc.edu.

Original languageEnglish (US)
Pages (from-to)92-106
Number of pages15
JournalProtein Science
Volume31
Issue number1
DOIs
StatePublished - Jan 2022

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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