@article{b372709d0e7645c2a816018c71187862,
title = "The evolution of the antimicrobial peptide database over 18 years: Milestones and new features",
abstract = "The antimicrobial peptide database (APD) has served the antimicrobial peptide field for 18 years. Because it is widely used in research and education, this article documents database milestones and key events that have transformed it into the current form. A comparison is made for the APD peptide statistics between 2010 and 2020, validating the major database findings to date. We also describe new additions ranging from peptide entries to search functions. Of note, the APD also contains antimicrobial peptides from host microbiota, which are important in shaping immune systems and could be linked to a variety of human diseases. Finally, the database has been re-programmed to the web branding and latest security compliance of the University of Nebraska Medical Center. The reprogrammed APD can be accessed at https://aps.unmc.edu.",
author = "Guangshun Wang and Zietz, {C. Michael} and Ashok Mudgapalli and Shuona Wang and Zhe Wang",
note = "Funding Information: The continued update and development of this database resource would be impossible without the consistent support of Dr. Steve Hinrichs, Professor and Chair, the Department of Pathology and Microbiology, UNMC. This study is supported by grants from the National Institutes of Health in the past and current GM138552, AI137161, as well as the University of Nebraska to GW. We thank Sriram Srinivasan, Deepak Khazanchi (UNO) and Joe Ziskovsky (UNMC) for establishing and maintaining a temporary APD3 website in the Amazon cloud during the reprograming of the APD. The support of the UNMC IT for over a decade is greatly appreciated. We thank Annie Wang for editing the final manuscript. Funding Information: The continued update and development of this database resource would be impossible without the consistent support of Dr. Steve Hinrichs, Professor and Chair, the Department of Pathology and Microbiology, UNMC. This study is supported by grants from the National Institutes of Health in the past and current GM138552, AI137161, as well as the University of Nebraska to GW. We thank Sriram Srinivasan, Deepak Khazanchi (UNO) and Joe Ziskovsky (UNMC) for establishing and maintaining a temporary APD3 website in the Amazon cloud during the reprograming of the APD. The support of the UNMC IT for over a decade is greatly appreciated. We thank Annie Wang for editing the final manuscript. Publisher Copyright: {\textcopyright} 2021 The Protein Society.",
year = "2022",
month = jan,
doi = "10.1002/pro.4185",
language = "English (US)",
volume = "31",
pages = "92--106",
journal = "Protein Science",
issn = "0961-8368",
publisher = "Cold Spring Harbor Laboratory Press",
number = "1",
}