The Evolution of the National Special Pathogen System of Care

Vikramjit Mukherjee, Lauren M. Sauer, Aneesh K. Mehta, Sophia Y. Shea, Paul D. Biddinger, Brendan G. Carr, Laura E. Evans, Shelly Schwedhelm, John J. Lowe

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Infectious disease outbreaks and pandemics have repeatedly threatened public health and have severely strained healthcare delivery systems throughout the past century. Pathogens causing respiratory illness, such as influenza viruses and coronaviruses, as well as the highly communicable viral hemorrhagic fevers, pose a large threat to the healthcare delivery system in the United States and worldwide. Through the Hospital Preparedness Program, within the US Department of Health and Human Services Office of the Assistant Secretary for Preparedness and Response, a nationwide Regional Ebola Treatment Network (RETN) was developed, building upon a state-and jurisdiction-based tiered hospital approach. This network, spearheaded by the National Emerging Special Pathogens Training and Education Center, developed a conceptual framework and plan for the evolution of the RETN into the National Special Pathogen System of Care (NSPS). Building the NSPS strategy involved reviewing the literature and the initial framework used in forming the RETN and conducting an extensive stakeholder engagement process to identify gaps and develop solutions. From this, the NSPS strategy and implementation plan were formed. The resulting NSPS strategy is an ambitious but critical effort that will have impacts on the mitigation efforts of special pathogen threats for years to come.

Original languageEnglish (US)
Pages (from-to)S39-S48
JournalHealth Security
Issue numberS1
StatePublished - Jun 1 2022
Externally publishedYes


  • Covid-19
  • Infectious diseases
  • National strategy/policy
  • Public health preparedness/response
  • Special pathogens
  • System of care

ASJC Scopus subject areas

  • Health(social science)
  • Emergency Medicine
  • Safety Research
  • Public Health, Environmental and Occupational Health
  • Management, Monitoring, Policy and Law
  • Health, Toxicology and Mutagenesis


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