The feasibility study of a hybrid coplanar arc technique versus hybrid intensity-modulated radiotherapy in treatment of early-stage left-sided breast cancer with simultaneous-integrated boost

Yuan Gui Chen, An Chuan Li, Wen Yao Li, Miao Yun Huang, Xiao Bo Li, Ming Qiu Chen, Mutian Zhang, Ben Hua Xu

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This study demonstrated the feasibility and advantages of a hybrid, volumetric arc therapy technique that used two 90° coplanar arcs and two three-dimensional conformal tangential beams in the simultaneous-integrated boost radiotherapy of left-sided breast cancer after breast-conserving surgery. A total of nine patients with stage I, left-sided breast cancer who underwent breast-conserving surgery were selected for this retrospective study. For each patient, a hybrid arc plan was generated and then compared with two hybrid intensity-modulated radiotherapy plans. All plans were optimized using the same objectives and dose constraints. The prescription dose was 50.4 Gy to the planning target volume with simultaneous boost to 60 Gy to the expanded gross target volume in 28 fractions. The differences among these hybrid plans were analyzed by the Kolmogorov-Smirnov test or the Wilcoxon rank sum test. The hybrid arc plans achieved the clinical requirements of target dose coverage and normal tissue (NT) dose constraints. It was found that the hybrid arc plans showed advantages in the conformity index of the expanded gross target volume, the V5of the heart, the D2of the left ventricle, and the D2and V50.4of NTs. The average beam-on time and monitor units of the hybrid arc plans were significantly lower (P < 0.001).

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Medical Physics
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Breast cancer
  • hybrid treatment plan
  • simultaneous-integrated boost
  • whole breast irradiation

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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