The fibroblast-populated collagen matrix as a model of wound healing: A review of the evidence

Mark A. Carlson, Michael T. Longaker

Research output: Contribution to journalReview article

117 Scopus citations

Abstract

The fibroblast-populated collagen matrix (FPCM) has been utilized as an in vitro model of wound healing for more than 2 decades. It offers a reasonable approximation of the healing wound during the phases of established granulation tissue and early scar. The gross and microscopic morphology of the FPCM and the healing wound are similar at analogous phases. The processes of proliferation, survival/apoptosis, protein synthesis, and contraction act in similar directions in these two models, and the response to exogenous agents also is consistent between them. If its limitations are respected, then the FPCM can be used as a model of the healing wound.

Original languageEnglish (US)
Pages (from-to)134-147
Number of pages14
JournalWound Repair and Regeneration
Volume12
Issue number2
DOIs
StatePublished - Mar 2004

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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