The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo

T. A. Lawson; A. S. Helgeson; C. J. Grandjean; L. Wallcave; D. Nagel

doi:10.1093/carcin/2.9.845

The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo

T. A. Lawson, A. S. Helgeson, C. J. Grandjean, L. Wallcave, D. Nagel

Eppley Institute for Cancer Research

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

After injection of N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg) to male Syrian golden hamsters there were higher concentrations of BOP and many of its metabolites in the hamster pancreas compared with the liver and salivary gland. Also, a potential methylating metabolite of BOP, N-nitrosomethyl(2-oxopropyl)amine, was found in both tissues.

Original language	English (US)
Pages (from-to)	845-849
Number of pages	5
Journal	Carcinogenesis
Volume	2
Issue number	9
DOIs	https://doi.org/10.1093/carcin/2.9.845
State	Published - 1981

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Cancer Research

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title = "The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo",

abstract = "After injection of N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg) to male Syrian golden hamsters there were higher concentrations of BOP and many of its metabolites in the hamster pancreas compared with the liver and salivary gland. Also, a potential methylating metabolite of BOP, N-nitrosomethyl(2-oxopropyl)amine, was found in both tissues.",

author = "Lawson, {T. A.} and Helgeson, {A. S.} and Grandjean, {C. J.} and L. Wallcave and D. Nagel",

note = "Funding Information: The study was supported by grant NO1 R26 CA20198 from the National Cancer Institute's National Pancreatic Cancer Project.",

year = "1981",

doi = "10.1093/carcin/2.9.845",

language = "English (US)",

volume = "2",

pages = "845--849",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

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T1 - The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo

AU - Lawson, T. A.

AU - Helgeson, A. S.

AU - Grandjean, C. J.

AU - Wallcave, L.

AU - Nagel, D.

N1 - Funding Information: The study was supported by grant NO1 R26 CA20198 from the National Cancer Institute's National Pancreatic Cancer Project.

PY - 1981

Y1 - 1981

N2 - After injection of N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg) to male Syrian golden hamsters there were higher concentrations of BOP and many of its metabolites in the hamster pancreas compared with the liver and salivary gland. Also, a potential methylating metabolite of BOP, N-nitrosomethyl(2-oxopropyl)amine, was found in both tissues.

AB - After injection of N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg) to male Syrian golden hamsters there were higher concentrations of BOP and many of its metabolites in the hamster pancreas compared with the liver and salivary gland. Also, a potential methylating metabolite of BOP, N-nitrosomethyl(2-oxopropyl)amine, was found in both tissues.

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U2 - 10.1093/carcin/2.9.845

DO - 10.1093/carcin/2.9.845

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EP - 849

JO - Carcinogenesis

JF - Carcinogenesis

IS - 9

ER -

The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo

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