The fundamental basis of inflammatory bowel disease

Warren Strober, Ivan Fuss, Peter Mannon

Research output: Contribution to journalArticle

921 Scopus citations

Abstract

Two broad hypotheses have arisen regarding the fundamental nature of the pathogenesis of inflammatory bowel diseases (IBDs, which include ulcerative colitis and Crohn disease). The first contends that primary dysregulation of the mucosal immune system leads to excessive immunologic responses to normal microflora. The second suggests that changes in the composition of gut microflora and/or deranged epithelial barrier function elicits pathologic responses from the normal mucosal immune system. Here we examine these hypotheses and conclude that IBD is indeed characterized by an abnormal mucosal immune response but that microbial factors and epithelial cell abnormalities can facilitate this response.

Original languageEnglish (US)
Pages (from-to)514-521
Number of pages8
JournalJournal of Clinical Investigation
Volume117
Issue number3
DOIs
StatePublished - Mar 1 2007

ASJC Scopus subject areas

  • Medicine(all)

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