The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-xL and Bcl-xS) that encode apoptotic regulatory proteins

Weiping Peng, Gail Henderson, Guey Chuen Perng, Anthony B. Nesburn, Steven L. Wechsler, Clinton Jones

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-xL transcript versus the Bcl-xS transcript in Neuro-2A cells. Bcl-xL encodes an antiapoptotic protein, whereas Bcl-xS encodes a proapoptotic protein. Promoting the accumulation of Bcl-xL in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.

Original languageEnglish (US)
Pages (from-to)10714-10718
Number of pages5
JournalJournal of virology
Volume77
Issue number19
DOIs
StatePublished - Oct 2003

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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