Abstract
Background: Callous-unemotional (CU) traits represent the affective features of psychopathy used to delineate youth at high risk for externalizing pathology. The genetic etiology CU traits is not currently well-understood. Methods: The current review surveyed the literature for studies on the genetic underpinnings of CU traits and integrated information from 39 genetic studies. Results: The results from 24 studies with quantitative data suggest that the heritability for CU traits is likely between 36–67%. A majority of the 16 molecular genetic studies focused on candidate genes in the serotonin and oxytocin systems with results that have not been well replicated. Although two genome-wide association studies have been conducted, no genome-wide significant loci have been discovered. Discussion: There is some evidence to suggest that the serotonin and oxytocin systems may play a role in CU traits; however, there is currently not enough evidence to implicate specific genetic mechanisms. The authors encourage researchers to continue to apply the most up-to-date and relevant methodology, specifically collaborations and consortiums using genome-wide and polygenic methods.
Original language | English (US) |
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Pages (from-to) | 85-97 |
Number of pages | 13 |
Journal | Neuroscience and Biobehavioral Reviews |
Volume | 100 |
DOIs | |
State | Published - May 2019 |
Keywords
- Callous
- Epigenetics
- Genetics
- Genomics
- Heritability
- Psychopathy
- Twins
- Uncaring
- Unemotional
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Cognitive Neuroscience
- Behavioral Neuroscience