The group B coxsackieviruses and myocarditis

Kyung Soo Kim, Günter Hufnagel, Nora M. Chapman, Steven Tracy

Research output: Contribution to journalReview article

127 Scopus citations

Abstract

The six serotypes of the group B coxsackieviruses (CVB) are common human enteroviruses linked etiologically to inflammatory cardiomyopathies. This has been demonstrated by molecular detection of enteroviral RNA in human heart tissue, serologic associations with disease, and virus isolation from cases of fulminant myocarditis. The murine model of CVB-associated myocarditis has demonstrated that CVB can be attenuated through mutations at different genomic sites. Human CVB3 isolates demonstrate varying degrees of cardiovirulence in the murine model; one site of virulence determination has been mapped to domain II of the 5′ non-translated region. The interplay of CVB replication and the immune response to that replication in the heart is a complex interaction determining the extent to which the virus replication is limited and the degree to which a pathogenic inflammation of cardiac muscle occurs. Studies of CVB3-induced myocarditis in murine strains lacking subsets of the immune system or genes regulating the immune response have demonstrated a pivotal role of the T cell response to the generation of myocarditis. While CVB are associated with 20-25% of cases of myocarditis or cardiomyopathy, the severity of the disease and the existence of attenuated strains shown to generate protective immunity in animal models indicates that vaccination against the CVBs would be valuable.

Original languageEnglish (US)
Pages (from-to)355-368
Number of pages14
JournalReviews in Medical Virology
Volume11
Issue number6
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    Kim, K. S., Hufnagel, G., Chapman, N. M., & Tracy, S. (2001). The group B coxsackieviruses and myocarditis. Reviews in Medical Virology, 11(6), 355-368. https://doi.org/10.1002/rmv.326