The H-ZKkm1 mutation: Nucleotide sequence and comparative analysis

John M. Martinko, Joyce C. Solheim, Jan Geliebter

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Nucleotide sequence analysis of mRNA from the class I murine MHC mutant H-2Kkml has established a site of mutation to be at the codon for amino acid position 152. Complete sequence information for the nucleotides coding for amino acids 136-163 demonstrates an A → C alteration at the codon for amino acid 152, changing Asp (GAT) in Kk to Ala (GCT) in Kkml. Several other murine and human class I MHC variants have similar alterations at amino acid position 152, resulting in altered biological activity. Finally, the pH-2III pseudogene of the H-2k haplotype has a GCT codon at amino acid position 152, suggesting that the GCT codon occurring in Kkml is the result of a gene conversion event.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalMolecular Immunology
Volume24
Issue number2
DOIs
StatePublished - Feb 1987

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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