The Hidden Conundrum of Phosphoinositide Signaling in Cancer

Narendra Thapa, Xiaojun Tan, Suyong Choi, Paul F. Lambert, Alan C. Rapraeger, Richard A. Anderson

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Phosphoinositide 3-kinase (PI3K) generation of PI(3,4,5)P3 from PI(4,5)P2 and the subsequent activation of Akt and its downstream signaling cascades (e.g., mTORC1) dominate the landscape of the phosphoinositide signaling axis in cancer research. However, PI(4,5)P2 is breaking its boundary as merely a substrate for PI3K and phospholipase C (PLC) and is now an established lipid messenger pivotal for various cellular events in cancer. Here we review the phosphoinositide signaling axis in cancer, giving due weight to PI(4,5)P2 and its generating enzymes, the phosphatidylinositol (PI) phosphate (PIP) kinases (PIPKs). We highlight how PI(4,5)P2 and PIPKs serve as a proximal node in the phosphoinositide signaling axis and how interaction with cytoskeletal proteins regulates the migratory and invasive nexus of metastasizing tumor cells.

Original languageEnglish (US)
Pages (from-to)378-390
Number of pages13
JournalTrends in Cancer
Issue number7
StatePublished - Jul 1 2016
Externally publishedYes


  • Akt
  • PI(3,4,5)P
  • PI(4,5)P
  • PI3K.
  • PIPKIγ

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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