TY - JOUR
T1 - The host microbiome regulates and maintains human health
T2 - A primer and perspective for non-microbiologists
AU - Thomas, Sunil
AU - Izard, Jacques
AU - Walsh, Emily
AU - Batich, Kristen
AU - Chongsathidkiet, Pakawat
AU - Clarke, Gerard
AU - Sela, David A.
AU - Muller, Alexander J.
AU - Mullin, James M.
AU - Albert, Korin
AU - Gilligan, John P.
AU - DiGuilio, Katherine
AU - Dilbarova, Rima
AU - Alexander, Walker
AU - Prendergast, George C.
N1 - Publisher Copyright:
© 2017 American Association for Cancer Research.
PY - 2017/4/15
Y1 - 2017/4/15
N2 - Humans consider themselves discrete autonomous organisms, but recent research is rapidly strengthening the appreciation that associated microorganisms make essential contributions to human health and well being. Each person is inhabited and also surrounded by his/her own signature microbial cloud. A low diversity of microorganisms is associated with a plethora of diseases, including allergy, diabetes, obesity, arthritis, inflammatory bowel diseases, and even neuropsychiatric disorders. Thus, an interaction of microorganisms with the host immune system is required for a healthy body. Exposure to microorganisms from themoment we are born and appropriate microbiome assembly during childhood are essential for establishing an active immune system necessary to prevent disease later in life. Exposure to microorganisms educates the immune system, induces adaptive immunity, and initiates memory B and T cells that are essential to combat various pathogens. The correct microbial-based education of immune cells may be critical in preventing the development of autoimmune diseases and cancer. This review provides a broad overview of the importance of the host microbiome and accumulating knowledge of how it regulates and maintains a healthy human system.
AB - Humans consider themselves discrete autonomous organisms, but recent research is rapidly strengthening the appreciation that associated microorganisms make essential contributions to human health and well being. Each person is inhabited and also surrounded by his/her own signature microbial cloud. A low diversity of microorganisms is associated with a plethora of diseases, including allergy, diabetes, obesity, arthritis, inflammatory bowel diseases, and even neuropsychiatric disorders. Thus, an interaction of microorganisms with the host immune system is required for a healthy body. Exposure to microorganisms from themoment we are born and appropriate microbiome assembly during childhood are essential for establishing an active immune system necessary to prevent disease later in life. Exposure to microorganisms educates the immune system, induces adaptive immunity, and initiates memory B and T cells that are essential to combat various pathogens. The correct microbial-based education of immune cells may be critical in preventing the development of autoimmune diseases and cancer. This review provides a broad overview of the importance of the host microbiome and accumulating knowledge of how it regulates and maintains a healthy human system.
UR - http://www.scopus.com/inward/record.url?scp=85018854841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018854841&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-16-2929
DO - 10.1158/0008-5472.CAN-16-2929
M3 - Review article
C2 - 28292977
AN - SCOPUS:85018854841
SN - 0008-5472
VL - 77
SP - 1783
EP - 1812
JO - Cancer Research
JF - Cancer Research
IS - 8
ER -