The host response in malaria and depression of defence against tuberculosis

G. C. Enwere, M. O. Ota, S. K. Obaro

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Malaria causes significant morbidity and mortality world-wide. Both asymptomatic and symptomatic malarial infections cause immune depression, which predisposes the host to infection with other micro-organisms. Specific clinical investigations have shown, for example, that those with malaria-attributable anaemia are particularly likely to have Salmonella septicaemia, and that asymptomatic malarial infection causes diminished response to polysaccharide vaccine. The results of clinical studies and experiments with animal models have revealed that malarial parasites can decrease their vertebrate host's effective humoral and cellular immune responses. In this review, the possible ways in which this malaria-induced immune impairment could affect the host's response to Mycobacterium tuberculosis infection are considered. Could malarial infection be one of the reasons for the persistence of tuberculosis in malaria-endemic regions?.

Original languageEnglish (US)
Pages (from-to)669-678
Number of pages10
JournalAnnals of Tropical Medicine and Parasitology
Volume93
Issue number7
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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