The human PECAM1 gene maps to 17q23

R. J. Gumina; N. E. Kirschbaum; P. N. Rao; P. VanTuinen; P. J. Newman

doi:10.1006/geno.1996.0272

The human PECAM1 gene maps to 17q23

R. J. Gumina, N. E. Kirschbaum, P. N. Rao, P. VanTuinen, P. J. Newman

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Abstract

We have determined the chromosomal and regional location of the gene encoding PECAM-1 (termed PECAM1 by GBD nomenclature) using a polymerase chain reaction (PCR)-based analysis of somatic cell hybrids. Analysis of a somatic cell hybrid chromosome panel established that the PECAM1 gene is on chromosome 17. Interestingly, several adhesion molecules expressed on platelets and endothelium also localize to chromosome 17: the GP1BA locus (glycoprotein (GP) Ibα) has been provisionally mapped to the region 17p12- pter, the ITGA2B (GPIIb) and the ITGB3 (GPI-IIa) loci have been confirmed to the region 17q21.32; and the ICAM2 locus has been provisionally mapped to the region 17q23-q25. To determine if the PECAM1 locus colocalizes with any of the loci for these adhesion molecules, PCR-based analysis of a regional mapping panel for human chromosome 17 was conducted. We found that the PECAM1 locus is on the long arm of chromosome 17, in the region q23-qter. To confirm this observation and obtain a more precise localization of the PECAM1 locus, fluorescence in situ hybridization was conducted. Together our data allowed assignment of the PECAM1 locus to the region 17q23.

Original language	English (US)
Pages (from-to)	229-232
Number of pages	4
Journal	Genomics
Volume	34
Issue number	2
DOIs	https://doi.org/10.1006/geno.1996.0272
State	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1006/geno.1996.0272

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title = "The human PECAM1 gene maps to 17q23",

abstract = "We have determined the chromosomal and regional location of the gene encoding PECAM-1 (termed PECAM1 by GBD nomenclature) using a polymerase chain reaction (PCR)-based analysis of somatic cell hybrids. Analysis of a somatic cell hybrid chromosome panel established that the PECAM1 gene is on chromosome 17. Interestingly, several adhesion molecules expressed on platelets and endothelium also localize to chromosome 17: the GP1BA locus (glycoprotein (GP) Ibα) has been provisionally mapped to the region 17p12- pter, the ITGA2B (GPIIb) and the ITGB3 (GPI-IIa) loci have been confirmed to the region 17q21.32; and the ICAM2 locus has been provisionally mapped to the region 17q23-q25. To determine if the PECAM1 locus colocalizes with any of the loci for these adhesion molecules, PCR-based analysis of a regional mapping panel for human chromosome 17 was conducted. We found that the PECAM1 locus is on the long arm of chromosome 17, in the region q23-qter. To confirm this observation and obtain a more precise localization of the PECAM1 locus, fluorescence in situ hybridization was conducted. Together our data allowed assignment of the PECAM1 locus to the region 17q23.",

author = "Gumina, {R. J.} and Kirschbaum, {N. E.} and Rao, {P. N.} and P. VanTuinen and Newman, {P. J.}",

note = "Funding Information: R.J.G. is the recipient of a Medical Scientist Training Fellowship from the Medical College of Wisconsin and a predoctoral fellowship from the American Heart Association, Wisconsin Af{\textregistered}liate. This work was supported by Grant HL40926 (to P.J.N.) and Training Grant HL-07209 from the National Institutes of Health. P.J.N. is an Established Investigator of the American Heart Association.",

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AU - Kirschbaum, N. E.

AU - Rao, P. N.

AU - VanTuinen, P.

AU - Newman, P. J.

N1 - Funding Information: R.J.G. is the recipient of a Medical Scientist Training Fellowship from the Medical College of Wisconsin and a predoctoral fellowship from the American Heart Association, Wisconsin Af®liate. This work was supported by Grant HL40926 (to P.J.N.) and Training Grant HL-07209 from the National Institutes of Health. P.J.N. is an Established Investigator of the American Heart Association.

PY - 1996

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N2 - We have determined the chromosomal and regional location of the gene encoding PECAM-1 (termed PECAM1 by GBD nomenclature) using a polymerase chain reaction (PCR)-based analysis of somatic cell hybrids. Analysis of a somatic cell hybrid chromosome panel established that the PECAM1 gene is on chromosome 17. Interestingly, several adhesion molecules expressed on platelets and endothelium also localize to chromosome 17: the GP1BA locus (glycoprotein (GP) Ibα) has been provisionally mapped to the region 17p12- pter, the ITGA2B (GPIIb) and the ITGB3 (GPI-IIa) loci have been confirmed to the region 17q21.32; and the ICAM2 locus has been provisionally mapped to the region 17q23-q25. To determine if the PECAM1 locus colocalizes with any of the loci for these adhesion molecules, PCR-based analysis of a regional mapping panel for human chromosome 17 was conducted. We found that the PECAM1 locus is on the long arm of chromosome 17, in the region q23-qter. To confirm this observation and obtain a more precise localization of the PECAM1 locus, fluorescence in situ hybridization was conducted. Together our data allowed assignment of the PECAM1 locus to the region 17q23.

AB - We have determined the chromosomal and regional location of the gene encoding PECAM-1 (termed PECAM1 by GBD nomenclature) using a polymerase chain reaction (PCR)-based analysis of somatic cell hybrids. Analysis of a somatic cell hybrid chromosome panel established that the PECAM1 gene is on chromosome 17. Interestingly, several adhesion molecules expressed on platelets and endothelium also localize to chromosome 17: the GP1BA locus (glycoprotein (GP) Ibα) has been provisionally mapped to the region 17p12- pter, the ITGA2B (GPIIb) and the ITGB3 (GPI-IIa) loci have been confirmed to the region 17q21.32; and the ICAM2 locus has been provisionally mapped to the region 17q23-q25. To determine if the PECAM1 locus colocalizes with any of the loci for these adhesion molecules, PCR-based analysis of a regional mapping panel for human chromosome 17 was conducted. We found that the PECAM1 locus is on the long arm of chromosome 17, in the region q23-qter. To confirm this observation and obtain a more precise localization of the PECAM1 locus, fluorescence in situ hybridization was conducted. Together our data allowed assignment of the PECAM1 locus to the region 17q23.

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The human PECAM1 gene maps to 17q23

Abstract

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