The immunophenotype of T-lymphoblastic lymphoma in children and adolescents: A children's oncology group report

Jay L. Patel, Lynette M. Smith, James Anderson, Minnie Abromowitch, Dario Campana, Jeffrey Jacobsen, Mark A. Lones, Thomas G. Gross, Mitchell S. Cairo, Sherrie L. Perkins

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40 Scopus citations

Abstract

T-lymphoblastic leukaemia (T-ALL) and T-lymphoblastic lymphoma (T-LBL) are neoplasms derived from immature lymphoid cells of T-cell lineage. These neoplasms are biologically similar, but significant differences may exist between the two given their clinical differences. Although ample data regarding the immunophenotypic characterization T-ALL are available, there is a paucity of such data in children and adolescents with T-LBL. We used flow cytometry and/or immunohistochemistry to characterize the immunophenotypic profile of 180 children and adolescents with newly diagnosed T-LBL enrolled in the Children's Oncology Group 5971 study. Multiple T-cell, B-cell, myeloid, and other markers were evaluated. We identified diagnostically useful immunophenotypic features of T-LBL as well as distinct immunophenotypic subgroups, although none of these was statistically related to event-free or overall survival in this retrospective analysis. Further studies of biologically and immunophenotypically distinct subgroups of T-LBL, such as the early T-cell precursor phenotype, are warranted.

Original languageEnglish (US)
Pages (from-to)454-461
Number of pages8
JournalBritish Journal of Haematology
Volume159
Issue number4
DOIs
StatePublished - Nov 2012

Keywords

  • Early T-cell precursor
  • Immunophenotypic analysis
  • Paediatric lymphoma
  • T-cell antigens
  • T-lymphoblastic lymphoma

ASJC Scopus subject areas

  • Hematology

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    Patel, J. L., Smith, L. M., Anderson, J., Abromowitch, M., Campana, D., Jacobsen, J., Lones, M. A., Gross, T. G., Cairo, M. S., & Perkins, S. L. (2012). The immunophenotype of T-lymphoblastic lymphoma in children and adolescents: A children's oncology group report. British Journal of Haematology, 159(4), 454-461. https://doi.org/10.1111/bjh.12042