The impact of left ventricle assist device on circulating endothelial microparticles - Pilot study

Jan Pitha, Zora Dorazilova, Vojtech Melenovsky, Ivana Kralova Lesna, Petr Stavek, Jitka Stepankova, Marian Urban, Jiri Maly, Ivan Netuka

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

OBJECTIVES: Recent technological breakthroughs in the design of reliable systems for long term non-pulsatile mechanical heart support offer the possibility to study the effect of continuous blood flow in the vascular system. Generally, it is assumed that the absence of physiological pulsatile flow leads to prothrombogenic and proatherogenic changes. We investigated the change in the circulating endothelial microparticle concentration as a marker of endothelial damage in patients implanted with a continuous-flow left ventricle assist device (LVAD). METHODS: Endothelial microparticles were measured in 8 males (mean age 54.1±11.5 years) with terminal heart failure before and 3 months after implantation of an LVAD. The group consisted of 3 patients with dilated cardiomyopathy, 3 patients with ischemic cardiomyopathy, 1 patient with both conditions and 1 patient with congenital valvular disease. The concentration of endothelial microparticles was determined by ELISA Zymutest MP activity test. RESULTS: We did not observe a significant change in the concentration of circulating endothelial microparticles measured before and 3 months after implantation (p=0.669). High inter-individual variability in response to implantation was found. However, no association between a change in endothelial microparticle concentration and heart failure aetiology or a significant clinical complication attributed to LVAD implantation was observed. CONCLUSION: Results from this preliminary pilot study do not indicate that LVADs contribute to short-term vascular damage as defined by an increase in circulating endothelial microparticles.

Original languageEnglish (US)
Pages (from-to)68-72
Number of pages5
JournalNeuroendocrinology Letters
Volume33
Issue numberSUPPL. 2
StatePublished - 2012

Keywords

  • Circulating endothelial microparticles
  • Endothelial dysfunction
  • Heart failure
  • Non-pulsatile flow
  • Ventricle assist device

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

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    Pitha, J., Dorazilova, Z., Melenovsky, V., Kralova Lesna, I., Stavek, P., Stepankova, J., Urban, M., Maly, J., & Netuka, I. (2012). The impact of left ventricle assist device on circulating endothelial microparticles - Pilot study. Neuroendocrinology Letters, 33(SUPPL. 2), 68-72.