The impact of neurally adjusted ventilatory assist mode on respiratory severity score and energy expenditure in infants: A randomized crossover trial

J. L. Rosterman, E. K. Pallotto, W. E. Truog, H. Escobar, K. A. Meinert, A. Holmes, H. Dai, W. M. Manimtim

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Objective:Examine respiratory severity scores (RSS) (mean airway pressure × fraction of inspired oxygen) and resting energy expenditure (REE) on neurally adjusted ventilatory assist (NAVA) compared with synchronized intermittent mandatory ventilation with pressure controlled and supported breath (SIMV (PC)PS).Study Design:A randomized, crossover trial in a level IV neonatal intensive care unit. Twenty-four patients were ventilated with NAVA or SIMV (PC) PS for 12 h and then crossed over to the alternative mode for 12 h. The primary outcome (RSS) and additional secondary respiratory outcomes were analyzed.Results:RSS and measured REE were not different between modes. On NAVA, peak inspiratory pressures were lower (17.8 vs 19.9 cmH 2 O (P<0.05)) without higher oxygen requirements. Respiratory rates were higher on NAVA (52 vs 39 (P<0.05)), estimated work of breathing (WOB) (0.01 vs 0.04 J l -1 (P<0.05)) was improved.Conclusion:NAVA mode can be safe without increase in RSS or REE. Although respiratory rates were higher, this was offset by lower peak inspiratory pressures and WOB during NAVA.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalJournal of Perinatology
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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