The impact of type 1 diabetes on neural activity serving attention

Christine M. Embury, Alex I. Wiesman, Timothy J. McDermott, Amy L. Proskovec, Elizabeth Heinrichs-Graham, Grace H. Lord, Kaitlin L. Brau, Andjela T. Drincic, Cyrus V. Desouza, Tony W. Wilson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Type 1 diabetes has been associated with alterations in attentional processing and other cognitive functions, and previous studies have found alterations in both brain structure and function in affected patients. However, these previous neuroimaging studies have generally examined older patients, particularly those with major comorbidities known to affect functioning independent of diabetes. The primary aim of the current study was to examine the neural dynamics of selective attention processing in a young group of patients with type 1 diabetes who were otherwise healthy (i.e., without major comorbidities). Our hypothesis was that these patients would exhibit significant aberrations in attention circuitry relative to closely matched controls. The final sample included 69 participants age 19–35 years old, 35 with type 1 diabetes and 34 matched nondiabetic controls, who completed an Eriksen flanker task while undergoing magnetoencephalography. Significant group differences in flanker interference activity were found across a network of brain regions, including the anterior cingulate, inferior parietal cortices, paracentral lobule, and the left precentral gyrus. In addition, neural activity in the anterior cingulate and the paracentral lobule was correlated with disease duration in patients with type 1 diabetes. These findings suggest that alterations in the neural circuitry underlying selective attention emerge early in the disease process and are specifically related to type 1 diabetes and not common comorbidities. These findings highlight the need for longitudinal studies in large cohorts to clarify the clinical implications of type 1 diabetes on cognition and the brain.

Original languageEnglish (US)
Pages (from-to)1093-1100
Number of pages8
JournalHuman Brain Mapping
Volume40
Issue number4
DOIs
StatePublished - Mar 2019

Keywords

  • alpha
  • conflict monitoring
  • flanker
  • magnetoencephalography
  • theta

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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