The importance of calcium in amphetamine-induced turning behavior in mice with unilateral nigro-striatal lesions

Y. K. Fung; N. J. Uretsky

doi:10.1016/0028-3908(80)90026-X

The importance of calcium in amphetamine-induced turning behavior in mice with unilateral nigro-striatal lesions

Y. K. Fung, N. J. Uretsky

Oral Biology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

This study was designed to examine the role of calcium in the amphetamine-induced turning behavior of mice lesioned with 6-hydroxydopamine. Intrastriatal administration of either saline or calcium had no effect on amphetamine-induced circling in lesioned mice. In contrast, intrastriatal administration of either EGTA, which chelates extracellular calcium, or verapamil, which inhibits calcium entry into cells, blocked the amphetamine-induced circling. The effect of EGTA was reveresd by the administration of calcium to the EGTA solution. At a dose that blocked amphetamine-induced circling, EGTA did not inhibit the circling produced by apomorphine. These results suggest that EGTA may exert its inhibitory effect on amphetamine-induced circling via a presynaptic mechanism.

Original language	English (US)
Pages (from-to)	555-560
Number of pages	6
Journal	Neuropharmacology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/0028-3908(80)90026-X
State	Published - Jun 1980

Keywords

EGTA
amphetamine
calcium
circling
striatum
verapamil

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(80)90026-X

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title = "The importance of calcium in amphetamine-induced turning behavior in mice with unilateral nigro-striatal lesions",

abstract = "This study was designed to examine the role of calcium in the amphetamine-induced turning behavior of mice lesioned with 6-hydroxydopamine. Intrastriatal administration of either saline or calcium had no effect on amphetamine-induced circling in lesioned mice. In contrast, intrastriatal administration of either EGTA, which chelates extracellular calcium, or verapamil, which inhibits calcium entry into cells, blocked the amphetamine-induced circling. The effect of EGTA was reveresd by the administration of calcium to the EGTA solution. At a dose that blocked amphetamine-induced circling, EGTA did not inhibit the circling produced by apomorphine. These results suggest that EGTA may exert its inhibitory effect on amphetamine-induced circling via a presynaptic mechanism.",

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