The importance of calcium in amphetamine-induced turning behavior in mice with unilateral nigro-striatal lesions

Y. K. Fung, N. J. Uretsky

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

This study was designed to examine the role of calcium in the amphetamine-induced turning behavior of mice lesioned with 6-hydroxydopamine. Intrastriatal administration of either saline or calcium had no effect on amphetamine-induced circling in lesioned mice. In contrast, intrastriatal administration of either EGTA, which chelates extracellular calcium, or verapamil, which inhibits calcium entry into cells, blocked the amphetamine-induced circling. The effect of EGTA was reveresd by the administration of calcium to the EGTA solution. At a dose that blocked amphetamine-induced circling, EGTA did not inhibit the circling produced by apomorphine. These results suggest that EGTA may exert its inhibitory effect on amphetamine-induced circling via a presynaptic mechanism.

Original languageEnglish (US)
Pages (from-to)555-560
Number of pages6
JournalNeuropharmacology
Volume19
Issue number6
DOIs
StatePublished - Jun 1980

Keywords

  • EGTA
  • amphetamine
  • calcium
  • circling
  • striatum
  • verapamil

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'The importance of calcium in amphetamine-induced turning behavior in mice with unilateral nigro-striatal lesions'. Together they form a unique fingerprint.

  • Cite this