The importance of nucleus accumbens in nicotine‐induced locomotor activity


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9 Scopus citations


Abstract— Bilateral injections of either nicotine (200 μg) or cytisine (30 or 60 μg) into the nucleus accumbens elicited locomotor hyperactivity in rats. Pretreatment with mecamylamine (2 mg kg−1, s.c.) was effective in attenuating the stimulatory effect of either nicotine or cytisine. This study suggests that nicotinic agonists such as nicotine and cytisine produce their locomotor excitatory effects through stimulation of the mesolimbic dopaminergic pathway. 1990 Royal Pharmaceutical Society of Great Britain

Original languageEnglish (US)
Pages (from-to)595-596
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Issue number8
StatePublished - Aug 1990

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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