The importance of nucleus accumbens in nicotine‐induced locomotor activity

YIU K. FUNG

doi:10.1111/j.2042-7158.1990.tb07069.x

The importance of nucleus accumbens in nicotine‐induced locomotor activity

YIU K. FUNG

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Abstract— Bilateral injections of either nicotine (200 μg) or cytisine (30 or 60 μg) into the nucleus accumbens elicited locomotor hyperactivity in rats. Pretreatment with mecamylamine (2 mg kg⁻¹, s.c.) was effective in attenuating the stimulatory effect of either nicotine or cytisine. This study suggests that nicotinic agonists such as nicotine and cytisine produce their locomotor excitatory effects through stimulation of the mesolimbic dopaminergic pathway. 1990 Royal Pharmaceutical Society of Great Britain

Original language	English (US)
Pages (from-to)	595-596
Number of pages	2
Journal	Journal of Pharmacy and Pharmacology
Volume	42
Issue number	8
DOIs	https://doi.org/10.1111/j.2042-7158.1990.tb07069.x
State	Published - Aug 1990
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1111/j.2042-7158.1990.tb07069.x

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AB - Abstract— Bilateral injections of either nicotine (200 μg) or cytisine (30 or 60 μg) into the nucleus accumbens elicited locomotor hyperactivity in rats. Pretreatment with mecamylamine (2 mg kg−1, s.c.) was effective in attenuating the stimulatory effect of either nicotine or cytisine. This study suggests that nicotinic agonists such as nicotine and cytisine produce their locomotor excitatory effects through stimulation of the mesolimbic dopaminergic pathway. 1990 Royal Pharmaceutical Society of Great Britain

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The importance of nucleus accumbens in nicotine‐induced locomotor activity

Abstract

ASJC Scopus subject areas

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