Abstract
The bICP0 protein encoded by bovine herpesvirus 1 stimulates productive infection and viral gene expression but inhibits interferon (IFN)-dependent transcription. bICP0 inhibits beta IFN (IFN-β) promoter activity and induces degradation of IFN regulatory factor 3 (IRF3). Although bICP0 inhibits the trans-activation activity of IRF7, IRF7 protein levels are not reduced. In this study, we demonstrate that bICP0 is associated with IRF7. Furthermore, bICP0 inhibits the ability of IRF7 to trans-activate the IFN-β promoter in the absence of IRF3 expression. The interaction between bICP0 and IRF7 correlates with reduced trans-activation of the IFN-β promoter by IRF7.
Original language | English (US) |
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Pages (from-to) | 3977-3981 |
Number of pages | 5 |
Journal | Journal of virology |
Volume | 83 |
Issue number | 8 |
DOIs | |
State | Published - Apr 2009 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology