Abstract
A self-complementary hexanucleotide consisting of thymidine and 2-aminodeoxyadenosine, d(TA'), has been synthesized by a solid phase phosphotriester method. Melting studies show that the additional hydrogen bond afforded by the 2-amino group substantially stabilizes the duplex. Moreover, conformational analysis using circulardichroim shows that a salt-induced conformational transition occurs, similar to the B→Z transition observed for d(CG)n oligonucleotides.
Original language | English (US) |
---|---|
Pages (from-to) | 4351-4361 |
Number of pages | 11 |
Journal | Nucleic acids research |
Volume | 10 |
Issue number | 14 |
DOIs | |
State | Published - Jul 24 1982 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics