The inheritance of psoriasis

Although a number of modes of genetic transmission have been proposed in psoriasis, an autosomal dominant pattern seems most consistent with available data. This suggests that an abnormality in a structural protein may be the underlying defect in the disease. The recent finding of a possible defect in the adenyl cyclase cyclic AMP cascade in the psoriatic epidermis suggests that a receptor site on the basal cell surface is a likely place to search for an altered protein.