TY - JOUR
T1 - The integrated National NeuroAIDS Tissue Consortium database
T2 - A rich platform for neuroHIV research
AU - Heithoff, Abigail J.
AU - Totusek, Steven A.
AU - Le, Duc
AU - Barwick, Lucas
AU - Gensler, Gary
AU - Franklin, Donald R.
AU - Dye, Allison C.
AU - Pandey, Sanjit
AU - Sherman, Seth
AU - Guda, Chittibabu
AU - Fox, Howard S.
N1 - Funding Information:
National Institutes of Health (U24MH100925; U24MH1 00928, U24MH100929, U24MH100930 and U24MH100 931 to NNTC sites; N01 MH22005, HHSN271201 000030C and HHS-N-271-2010-00036C to CHARTER studies).
PY - 2019/1/8
Y1 - 2019/1/8
N2 - Herein we present major updates to the National NeuroAIDS Tissue Consortium (NNTC) database. The NNTC's ongoing multisite clinical research study was established to facilitate access to ante-mortem and post-mortem data, tissues and biofluids for the neurohuman immunodeficiency virus (HIV) research community. Recently, the NNTC has expanded to include data from the central nervous system HIV Antiretroviral Therapy Effects Research (CHARTER) study. The data and biospecimens from CHARTER and NNTC cohorts are available to qualified researchers upon request. Data generated by requestors using NNTC biospecimens and tissues are returned to the NNTC upon the conclusion of requestors' work, and this external, experimental data are annotated and curated in the publically accessible NNTC database, thereby extending the utility of each case. A flexible and extensible database ontology allows the integration of disparate data sets, including external experimental data, clinical neuropsychological and neuromedical testing data, tissue pathology and neuroimaging data.
AB - Herein we present major updates to the National NeuroAIDS Tissue Consortium (NNTC) database. The NNTC's ongoing multisite clinical research study was established to facilitate access to ante-mortem and post-mortem data, tissues and biofluids for the neurohuman immunodeficiency virus (HIV) research community. Recently, the NNTC has expanded to include data from the central nervous system HIV Antiretroviral Therapy Effects Research (CHARTER) study. The data and biospecimens from CHARTER and NNTC cohorts are available to qualified researchers upon request. Data generated by requestors using NNTC biospecimens and tissues are returned to the NNTC upon the conclusion of requestors' work, and this external, experimental data are annotated and curated in the publically accessible NNTC database, thereby extending the utility of each case. A flexible and extensible database ontology allows the integration of disparate data sets, including external experimental data, clinical neuropsychological and neuromedical testing data, tissue pathology and neuroimaging data.
UR - http://www.scopus.com/inward/record.url?scp=85059797010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059797010&partnerID=8YFLogxK
U2 - 10.1093/database/bay134
DO - 10.1093/database/bay134
M3 - Article
C2 - 30624650
AN - SCOPUS:85059797010
VL - 2019
JO - Database : the journal of biological databases and curation
JF - Database : the journal of biological databases and curation
SN - 1758-0463
M1 - bay134
ER -