The interpeduncular nucleus

Barbara J. Morley

doi:10.1016/S0074-7742(08)60108-7

The interpeduncular nucleus

Barbara J. Morley

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

The interpeduncular nucleus (IPN) is a phylogenetically conserved area of the brain. Anatomically, the IPN is unique in that it is primarily an unpaired structure, but receives a significant input from a paired structure, the habenula (Hb). Solely based on its anatomical connections it can be concluded that the IPN is an important integrative center for the limbic system. The IPN is highly vascularized and protrudes into the interpeduncular cistern. In some species, IPN cells having morphologic similarities to neurosecretory cells are identified. An important aspect of both the neurochemical and neuroanatomical understanding of the IPN is to determine whether important species differences exist. The observation that the biochemical measurements indicate extremely high concentrations of acetylcholine (ACh) and choline acetyltransferase (CAT) is in agreement with reports that the IPN contains a high concentration of the binding of [³H]ACh as well as other receptor ligands. Metabolic activity in the IPN is spared or increased during anesthesia, suggesting several possible behavioral functions related to sleep, to autonomic functions such as respiration, or to a generalized emotional state.

Original language	English (US)
Pages (from-to)	157-182
Number of pages	26
Journal	International Review of Neurobiology
Volume	28
Issue number	C
DOIs	https://doi.org/10.1016/S0074-7742(08)60108-7
State	Published - Jan 1986

ASJC Scopus subject areas

Clinical Neurology
Cellular and Molecular Neuroscience

Access to Document

10.1016/S0074-7742(08)60108-7

Cite this

@article{c99d7de1ddde4f32b4ec2eb0333e2f21,

title = "The interpeduncular nucleus",

abstract = "The interpeduncular nucleus (IPN) is a phylogenetically conserved area of the brain. Anatomically, the IPN is unique in that it is primarily an unpaired structure, but receives a significant input from a paired structure, the habenula (Hb). Solely based on its anatomical connections it can be concluded that the IPN is an important integrative center for the limbic system. The IPN is highly vascularized and protrudes into the interpeduncular cistern. In some species, IPN cells having morphologic similarities to neurosecretory cells are identified. An important aspect of both the neurochemical and neuroanatomical understanding of the IPN is to determine whether important species differences exist. The observation that the biochemical measurements indicate extremely high concentrations of acetylcholine (ACh) and choline acetyltransferase (CAT) is in agreement with reports that the IPN contains a high concentration of the binding of [3H]ACh as well as other receptor ligands. Metabolic activity in the IPN is spared or increased during anesthesia, suggesting several possible behavioral functions related to sleep, to autonomic functions such as respiration, or to a generalized emotional state.",

author = "Morley, {Barbara J.}",

year = "1986",

month = jan,

doi = "10.1016/S0074-7742(08)60108-7",

language = "English (US)",

volume = "28",

pages = "157--182",

journal = "International Review of Neurobiology",

issn = "0074-7742",

publisher = "Academic Press Inc.",

number = "C",

}

TY - JOUR

T1 - The interpeduncular nucleus

AU - Morley, Barbara J.

PY - 1986/1

Y1 - 1986/1

N2 - The interpeduncular nucleus (IPN) is a phylogenetically conserved area of the brain. Anatomically, the IPN is unique in that it is primarily an unpaired structure, but receives a significant input from a paired structure, the habenula (Hb). Solely based on its anatomical connections it can be concluded that the IPN is an important integrative center for the limbic system. The IPN is highly vascularized and protrudes into the interpeduncular cistern. In some species, IPN cells having morphologic similarities to neurosecretory cells are identified. An important aspect of both the neurochemical and neuroanatomical understanding of the IPN is to determine whether important species differences exist. The observation that the biochemical measurements indicate extremely high concentrations of acetylcholine (ACh) and choline acetyltransferase (CAT) is in agreement with reports that the IPN contains a high concentration of the binding of [3H]ACh as well as other receptor ligands. Metabolic activity in the IPN is spared or increased during anesthesia, suggesting several possible behavioral functions related to sleep, to autonomic functions such as respiration, or to a generalized emotional state.

AB - The interpeduncular nucleus (IPN) is a phylogenetically conserved area of the brain. Anatomically, the IPN is unique in that it is primarily an unpaired structure, but receives a significant input from a paired structure, the habenula (Hb). Solely based on its anatomical connections it can be concluded that the IPN is an important integrative center for the limbic system. The IPN is highly vascularized and protrudes into the interpeduncular cistern. In some species, IPN cells having morphologic similarities to neurosecretory cells are identified. An important aspect of both the neurochemical and neuroanatomical understanding of the IPN is to determine whether important species differences exist. The observation that the biochemical measurements indicate extremely high concentrations of acetylcholine (ACh) and choline acetyltransferase (CAT) is in agreement with reports that the IPN contains a high concentration of the binding of [3H]ACh as well as other receptor ligands. Metabolic activity in the IPN is spared or increased during anesthesia, suggesting several possible behavioral functions related to sleep, to autonomic functions such as respiration, or to a generalized emotional state.

UR - http://www.scopus.com/inward/record.url?scp=0022964275&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022964275&partnerID=8YFLogxK

U2 - 10.1016/S0074-7742(08)60108-7

DO - 10.1016/S0074-7742(08)60108-7

M3 - Article

C2 - 2433243

AN - SCOPUS:0022964275

SN - 0074-7742

VL - 28

SP - 157

EP - 182

JO - International Review of Neurobiology

JF - International Review of Neurobiology

IS - C

ER -

The interpeduncular nucleus

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this