4 Scopus citations

Abstract

The isoprenoid biosynthetic pathway (IBP) is the source of a vast array of isoprenoids. This pathway is highly conserved and isoprenoids play key roles throughout all forms of life. The discovery and development of the statins, a class of drugs which inhibit the rate-limiting step in the mevalonate- dependent IBP, has led to improved scientific understanding of the complex regulation of the pathway and has provided therapeutic agents which have had far-reaching effects on human health. Here, we provide an overview of the IBP and discuss the impact of pharmacological manipulation of the pathway by the statins.

Original languageEnglish (US)
Title of host publicationEnzymes
PublisherAcademic Press
Pages279-299
Number of pages21
DOIs
StatePublished - 2011

Publication series

NameEnzymes
Volume30
ISSN (Print)1874-6047

Keywords

  • Isoprenoid biosynthetic pathway
  • Mevalonate kinase
  • Myopathy
  • Statins
  • Synthetic statins
  • Ubiquinone

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biochemistry
  • Molecular Biology

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