@inbook{ed5d1227927d48e1a5bcf2d37a634842,
title = "The Isoprenoid Biosynthetic Pathway and Statins",
abstract = "The isoprenoid biosynthetic pathway (IBP) is the source of a vast array of isoprenoids. This pathway is highly conserved and isoprenoids play key roles throughout all forms of life. The discovery and development of the statins, a class of drugs which inhibit the rate-limiting step in the mevalonate- dependent IBP, has led to improved scientific understanding of the complex regulation of the pathway and has provided therapeutic agents which have had far-reaching effects on human health. Here, we provide an overview of the IBP and discuss the impact of pharmacological manipulation of the pathway by the statins.",
keywords = "Isoprenoid biosynthetic pathway, Mevalonate kinase, Myopathy, Statins, Synthetic statins, Ubiquinone",
author = "Holstein, {Sarah A.}",
year = "2011",
doi = "10.1016/B978-0-12-415922-8.00012-4",
language = "English (US)",
series = "Enzymes",
publisher = "Academic Press",
pages = "279--299",
booktitle = "Enzymes",
}