The laminins in the murine inner ear: Developmental transitions and expression in cochlear basement membranes

Kathyrn D. Rodgers, Laura Barritt, Jeffery H. Miner, Dominic Cosgrove

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The laminins are a family of heterotrimeric extracellular matrix molecules that form suprastructural networks in basement membranes and elsewhere. They interact with integrin receptors, playing key roles in modulating programs of cytodifferentiation and maintaining tissue homeostasis in animals. Earlier studies have demonstrated an extensive laminin network in both the developing and adult cochlea, primarily associated with the basement membranes. These studies, however, did not address the laminin chain composition of these networks. In this study, we used antibodies specific for the known laminin chains to examine the composition of laminins in both the developing and adult murine cochlea. The results illustrate a complex and dynamic postnatal developmental regulation pattern for most of these chains, and suggest that an unusually large number of laminin heterotrimers are present in both the developing and adult cochlea. The laminin composition at postnatal day 2 is relatively simple. By postnatal day 7, however, activation of several laminin chains results in a very complex laminin composition. In the basement membrane underlying the region of the basilar membrane under the developing organ of Corti, eight of the 11 known basement membrane laminins are possible by co-localization inference. Dynamic changes in expression continue through day 14, but simplify by adulthood. Thus, the most dynamic period for laminin expression in the mouse cochlea coincides with terminal cytodifferentiation of the cochlear epithelial structures. Considering the well established role of laminins in regulating both embryonic and organ development in other systems, these data suggest a closer look at the role of the laminins in cochlear development and function may be warranted.

Original languageEnglish (US)
Pages (from-to)39-50
Number of pages12
JournalHearing Research
Issue number1-2
StatePublished - 2001


  • Basement membrane
  • Cochlea
  • Development
  • Laminin

ASJC Scopus subject areas

  • Sensory Systems


Dive into the research topics of 'The laminins in the murine inner ear: Developmental transitions and expression in cochlear basement membranes'. Together they form a unique fingerprint.

Cite this