The latency-related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection

Gail Henderson, Guey Chuen Perng, Anthony B. Nesburn, Steven L. Wechsler, Clinton Jones

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3 cleavage during productive infection. Plasmids containing LAT or the LR gene inhibit caspase 3 activation in transiently transfected cells, suggesting productive infection blocks certain antiapoptotic properties of LAT. These studies demonstrate a correlation between the enhanced pathogenic potential of CJLAT and the LR gene inhibiting caspase 3 cleavage during productive infection.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
JournalJournal of neurovirology
Volume10
Issue number1
DOIs
StatePublished - Feb 2004

Keywords

  • Apoptosis
  • Bovine herpesvirus 1 (BHV-1) latency related (LR) gene
  • Caspase cleavage

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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