TY - JOUR
T1 - The lifespan trajectory of neural oscillatory activity in the motor system
AU - Heinrichs-Graham, Elizabeth
AU - McDermott, Timothy J.
AU - Mills, Mackenzie S.
AU - Wiesman, Alex I.
AU - Wang, Yu Ping
AU - Stephen, Julia M.
AU - Calhoun, Vince D.
AU - Wilson, Tony W.
N1 - Funding Information:
This work was supported by the National Institutes of Health ( R01 MH103220 to TWW), the National Science Foundation ( #1539067 to Y-PW, JMS, VDC, and TWW), and the Shoemaker Prize from the University of Nebraska Foundation to TWW. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors declare no competing financial or non-financial interests.
Publisher Copyright:
© 2018
PY - 2018/4
Y1 - 2018/4
N2 - Numerous studies connect beta oscillations in the motor cortices to volitional movement, and beta is known to be aberrant in multiple movement disorders. However, the dynamic interplay between these beta oscillations, motor performance, and spontaneous beta power (e.g., during rest) in the motor cortices remains unknown. This study utilized magnetoencephalography (MEG) to investigate these three parameters and their lifespan trajectory in 57 healthy participants aged 9–75 years old. Movement-related beta activity was imaged using a beamforming approach, and voxel time series data were extracted from the peak voxels in the primary motor cortices. Our results indicated that spontaneous beta power during rest followed a quadratic lifespan trajectory, while movement-related beta oscillations linearly increased with age. Follow-on analyses showed that spontaneous beta power and the beta minima during movement, together, significantly predicted task performance above and beyond the effects of age. These data are the first to show lifespan trajectories among measures of beta activity in the motor cortices, and suggest that the healthy brain compensates for age-related increases in spontaneous beta activity by increasing the strength of beta oscillations within the motor cortices which, when successful, enables normal motor performance into later life.
AB - Numerous studies connect beta oscillations in the motor cortices to volitional movement, and beta is known to be aberrant in multiple movement disorders. However, the dynamic interplay between these beta oscillations, motor performance, and spontaneous beta power (e.g., during rest) in the motor cortices remains unknown. This study utilized magnetoencephalography (MEG) to investigate these three parameters and their lifespan trajectory in 57 healthy participants aged 9–75 years old. Movement-related beta activity was imaged using a beamforming approach, and voxel time series data were extracted from the peak voxels in the primary motor cortices. Our results indicated that spontaneous beta power during rest followed a quadratic lifespan trajectory, while movement-related beta oscillations linearly increased with age. Follow-on analyses showed that spontaneous beta power and the beta minima during movement, together, significantly predicted task performance above and beyond the effects of age. These data are the first to show lifespan trajectories among measures of beta activity in the motor cortices, and suggest that the healthy brain compensates for age-related increases in spontaneous beta activity by increasing the strength of beta oscillations within the motor cortices which, when successful, enables normal motor performance into later life.
KW - Beta ERD
KW - Magnetoencephalography
KW - Motor control
KW - Movement
KW - Precentral gyrus
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U2 - 10.1016/j.dcn.2018.02.013
DO - 10.1016/j.dcn.2018.02.013
M3 - Article
C2 - 29525417
AN - SCOPUS:85043346442
SN - 1878-9293
VL - 30
SP - 159
EP - 168
JO - Developmental Cognitive Neuroscience
JF - Developmental Cognitive Neuroscience
ER -