TY - JOUR
T1 - The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate
AU - Bouzid, Tasneem
AU - Kim, Eunju
AU - Riehl, Brandon D.
AU - Esfahani, Amir Monemian
AU - Rosenbohm, Jordan
AU - Yang, Ruiguo
AU - Duan, Bin
AU - Lim, Jung Yul
N1 - Publisher Copyright:
© 2019 The Author(s).
PY - 2019/8/7
Y1 - 2019/8/7
N2 - Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue engineering and regenerative medicine, and are understood to be mechanosensitive to external mechanical environments. In recent years, increasing evidence points to nuclear envelope proteins as a key player in sensing and relaying mechanical signals in MSCs to modulate cellular form, function, and differentiation. Of particular interest is the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex that includes nesprin and SUN. In this review, the way in which cells can sense external mechanical environments through an intact nuclear envelope and LINC complex proteins will be briefly described. Then, we will highlight the current body of literature on the role of the LINC complex in regulating MSC function and fate decision, without and with external mechanical loading conditions. Our review and suggested future perspective may provide a new insight into the understanding of MSC mechanobiology and related functional tissue engineering applications.
AB - Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue engineering and regenerative medicine, and are understood to be mechanosensitive to external mechanical environments. In recent years, increasing evidence points to nuclear envelope proteins as a key player in sensing and relaying mechanical signals in MSCs to modulate cellular form, function, and differentiation. Of particular interest is the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex that includes nesprin and SUN. In this review, the way in which cells can sense external mechanical environments through an intact nuclear envelope and LINC complex proteins will be briefly described. Then, we will highlight the current body of literature on the role of the LINC complex in regulating MSC function and fate decision, without and with external mechanical loading conditions. Our review and suggested future perspective may provide a new insight into the understanding of MSC mechanobiology and related functional tissue engineering applications.
KW - Functional tissue engineering
KW - Linker of Nucleoskeleton and cytoskeleton (LINC)
KW - Mechanotransduction
KW - Mesenchymal stem cells
KW - Nesprin
KW - SUN
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UR - http://www.scopus.com/inward/citedby.url?scp=85072012336&partnerID=8YFLogxK
U2 - 10.1186/s13036-019-0197-9
DO - 10.1186/s13036-019-0197-9
M3 - Review article
C2 - 31406505
AN - SCOPUS:85072012336
SN - 1754-1611
VL - 13
JO - Journal of Biological Engineering
JF - Journal of Biological Engineering
IS - 1
M1 - 68
ER -