The lymphatic system and pancreatic cancer

Darci M. Fink, Maria M. Steele, Michael A. Hollingsworth

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


This review summarizes current knowledge of the biology, pathology and clinical understanding of lymphatic invasion and metastasis in pancreatic cancer. We discuss the clinical and biological consequences of lymphatic invasion and metastasis, including paraneoplastic effects on immune responses and consider the possible benefit of therapies to treat tumors that are localized to lymphatics. A review of current techniques and methods to study interactions between tumors and lymphatics is presented.

Original languageEnglish (US)
Pages (from-to)217-236
Number of pages20
JournalCancer Letters
Issue number1
StatePublished - Oct 10 2016


  • Lymph node
  • Lymphatics
  • Pancreatic cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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