The mechanisms by which growth hormone brings about growth: The relative contributions of growth hormone and insulin-like growth factors

A. Spagnoli, R. G. Rosenfeld

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Growth hormone is the major regulator of postnatal growth. Although intrauterine growth seems to be largely growth hormone independent, gene knockout studies have established the pivotal role of the IGF system in both prenatal and postnatal growth. The original 'somatomedin hypothesis' postulated that all of the growth-promoting actions of growth hormone were mediated by IGFs. Several in vitro and in vivo studies have suggested, however, that growth hormone may have specific growth-related actions in addition to stimulating IGF production, including promoting differentiation of prechondrocytes at the growth plate and stimulation of synthesis of proteins involved in IGF transport and clearance. An integrated model of interrelated role(s) of growth hormone and IGF in skeletal growth is proposed.

Original languageEnglish (US)
Pages (from-to)615-631
Number of pages17
JournalEndocrinology and Metabolism Clinics of North America
Volume25
Issue number3
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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