TY - JOUR
T1 - The metabolic basis of recovery after fatiguing exercise of human muscle
AU - Boska, M. D.
AU - Moussavi, R. S.
AU - Carson, P. J.
AU - Weiner, M. W.
AU - Miller, Robert G.
PY - 1990/2
Y1 - 1990/2
N2 - We investigated the metabolic basis of human muscular fatigue and recovery utilizing 31P magnetic resonance spectroscopy and measurements of maximum voluntary contraction (MVC). We produced fatigue by sustained MVC for 4 minutes in 2 different muscles (adductor pollicis, tibialis anterior) and obtained similar results in both muscles. During fatiguing exercise, there was a nonlinear relationship between MVC and both phosphocreatine and total inorganic phosphate. By contrast, there was a roughly linear relationship between the decline in MVC and the accumulation of both H+ and H2PO4-. However, during recovery after exercise, MVC rapidly returned to control levels while H+ recovered with a much slower time course. On the other hand, H2PO4- rapidly returned to control values with a time course similar to MVC. In addition, the relationship of H2PO4- to MVC was similar during both fatigue and recovery. Thus, during fatigue as well as during recovery, changes in MVC correlate best with H2PO4-, suggesting that this metabolite is an important factor in human muscle fatigue.
AB - We investigated the metabolic basis of human muscular fatigue and recovery utilizing 31P magnetic resonance spectroscopy and measurements of maximum voluntary contraction (MVC). We produced fatigue by sustained MVC for 4 minutes in 2 different muscles (adductor pollicis, tibialis anterior) and obtained similar results in both muscles. During fatiguing exercise, there was a nonlinear relationship between MVC and both phosphocreatine and total inorganic phosphate. By contrast, there was a roughly linear relationship between the decline in MVC and the accumulation of both H+ and H2PO4-. However, during recovery after exercise, MVC rapidly returned to control levels while H+ recovered with a much slower time course. On the other hand, H2PO4- rapidly returned to control values with a time course similar to MVC. In addition, the relationship of H2PO4- to MVC was similar during both fatigue and recovery. Thus, during fatigue as well as during recovery, changes in MVC correlate best with H2PO4-, suggesting that this metabolite is an important factor in human muscle fatigue.
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U2 - 10.1212/wnl.40.2.240
DO - 10.1212/wnl.40.2.240
M3 - Article
C2 - 2300242
AN - SCOPUS:0025275645
SN - 0028-3878
VL - 40
SP - 240
EP - 244
JO - Neurology
JF - Neurology
IS - 2
ER -