The mitochondrial dynamics of alzheimer's disease and parkinson's disease offer important opportunities for therapeutic intervention

David J. Bonda, Mark A. Smith, George Perry, Hyoung gon Lee, Xinglong Wang, Xiongwei Zhu

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Mitochondrial dynamics play a crucial role in the pathobiology underlying Alzheimer's disease (AD) and Parkinson's disease (PD). Although a complete scientific understanding of these devastating conditions has yet to be realized, alterations in mitochondrial fis- sion and fusion, and in the protein complexes that orchestrate mitochondrial fission and fusion, have been well established in AD-and PD-related neurodegeneration. Whether fission/fusion disruption in the brain is a causal agent in neuronal demise or a product of some other upstream disturbance is still a matter of debate; however, in both AD and PD, the potential for successful therapeutic amelioration of degeneration via mitochondrial protection is high. We here discuss the role of mitochondrial dynamics in AD and PD and assess the need for their therapeutic exploitation.

Original languageEnglish (US)
Pages (from-to)3374-3380
Number of pages7
JournalCurrent Pharmaceutical Design
Volume17
Issue number31
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Dlp-1
  • Drp-1
  • Fis1
  • Fission
  • Fusion
  • Mfn1
  • Mfn2
  • Mitochondrial dynamics
  • Neurodegeneration
  • Parkinson's disease
  • Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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