The nature of processing speed deficits in traumatic brain injury: Is less brain more?

Frank G. Hillary, Helen M. Genova, John D. Medaglia, Neal M. Fitzpatrick, Kathy S. Chiou, Britney M. Wardecker, Robert G. Franklin, Jianli Wang, John DeLuca

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The cognitive constructs working memory (WM) and processing speed are fundamental components to general intellectual functioning in humans and highly susceptible to disruption following neurological insult. Much of the work to date examining speeded working memory deficits in clinical samples using functional imaging has demonstrated recruitment of network areas including prefrontal cortex (PFC) and anterior cingulate cortex (ACC). What remains unclear is the nature of this neural recruitment. The goal of this study was to isolate the neural networks distinct from those evident in healthy adults and to determine if reaction time (RT) reliably predicts observable between-group differences. The current data indicate that much of the neural recruitment in TBI during a speeded visual scanning task is positively correlated with RT. These data indicate that recruitment in PFC during tasks of rapid information processing are at least partially attributable to normal recruitment of PFC support resources during slowed task processing.

Original languageEnglish (US)
Pages (from-to)141-154
Number of pages14
JournalBrain Imaging and Behavior
Volume4
Issue number2
DOIs
StatePublished - 2010

Keywords

  • Processing speed
  • Reorganization
  • TBI
  • Working memory
  • fMRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

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    Hillary, F. G., Genova, H. M., Medaglia, J. D., Fitzpatrick, N. M., Chiou, K. S., Wardecker, B. M., Franklin, R. G., Wang, J., & DeLuca, J. (2010). The nature of processing speed deficits in traumatic brain injury: Is less brain more? Brain Imaging and Behavior, 4(2), 141-154. https://doi.org/10.1007/s11682-010-9094-z