TY - JOUR
T1 - The nervous system and innate immunity
T2 - The neuropeptide connection
AU - Brogden, Kim A.
AU - Guthmiller, Janet M.
AU - Salzet, Michel
AU - Zasloff, Michael
N1 - Funding Information:
We thank M. Marti for preparation of the figures. Supported by the National Institute of Dental and Craniofacial Research (1 R01 DE014390-01A2), National Institutes of Health (K.A.B.) and the Centre National de la Recherche Scientifique, Ministére de la Recherche et des Technologies, National Institutes of Health– Forgarty, Fondation pour la Recherche Médicale and Génopole-Lille (M.S.).
PY - 2005
Y1 - 2005
N2 - Many neuropeptides and peptide hormones are very similar to antimicrobial peptides in their amino acid composition, amphipathic design, cationic charge and size. Their antimicrobial activities suggest they may also be directly involved in innate defense. Here we discuss recent advances in understanding how the mammalian nervous system, equipped with neuropeptides and peptide hormones with potent antimicrobial properties, might directly defend the host from microbial assault. As examples, we have chosen five well described, locally produced neuropeptides that may serve a previously unrecognized, direct antimicrobial, innate immune function in four anatomical sites.
AB - Many neuropeptides and peptide hormones are very similar to antimicrobial peptides in their amino acid composition, amphipathic design, cationic charge and size. Their antimicrobial activities suggest they may also be directly involved in innate defense. Here we discuss recent advances in understanding how the mammalian nervous system, equipped with neuropeptides and peptide hormones with potent antimicrobial properties, might directly defend the host from microbial assault. As examples, we have chosen five well described, locally produced neuropeptides that may serve a previously unrecognized, direct antimicrobial, innate immune function in four anatomical sites.
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U2 - 10.1038/ni1209
DO - 10.1038/ni1209
M3 - Review article
C2 - 15908937
AN - SCOPUS:20644432642
VL - 6
SP - 558
EP - 564
JO - Nature Immunology
JF - Nature Immunology
SN - 1529-2908
IS - 6
ER -