The nervous system and innate immunity: The neuropeptide connection

Kim A. Brogden; Janet M. Guthmiller; Michel Salzet; Michael Zasloff

doi:10.1038/ni1209

The nervous system and innate immunity: The neuropeptide connection

Kim A. Brogden, Janet M. Guthmiller, Michel Salzet, Michael Zasloff

Research output: Contribution to journal › Review article › peer-review

188 Scopus citations

Abstract

Many neuropeptides and peptide hormones are very similar to antimicrobial peptides in their amino acid composition, amphipathic design, cationic charge and size. Their antimicrobial activities suggest they may also be directly involved in innate defense. Here we discuss recent advances in understanding how the mammalian nervous system, equipped with neuropeptides and peptide hormones with potent antimicrobial properties, might directly defend the host from microbial assault. As examples, we have chosen five well described, locally produced neuropeptides that may serve a previously unrecognized, direct antimicrobial, innate immune function in four anatomical sites.

Original language	English (US)
Pages (from-to)	558-564
Number of pages	7
Journal	Nature Immunology
Volume	6
Issue number	6
DOIs	https://doi.org/10.1038/ni1209
State	Published - 2005

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/ni1209

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title = "The nervous system and innate immunity: The neuropeptide connection",

abstract = "Many neuropeptides and peptide hormones are very similar to antimicrobial peptides in their amino acid composition, amphipathic design, cationic charge and size. Their antimicrobial activities suggest they may also be directly involved in innate defense. Here we discuss recent advances in understanding how the mammalian nervous system, equipped with neuropeptides and peptide hormones with potent antimicrobial properties, might directly defend the host from microbial assault. As examples, we have chosen five well described, locally produced neuropeptides that may serve a previously unrecognized, direct antimicrobial, innate immune function in four anatomical sites.",

author = "Brogden, {Kim A.} and Guthmiller, {Janet M.} and Michel Salzet and Michael Zasloff",

note = "Funding Information: We thank M. Marti for preparation of the figures. Supported by the National Institute of Dental and Craniofacial Research (1 R01 DE014390-01A2), National Institutes of Health (K.A.B.) and the Centre National de la Recherche Scientifique, Minist{\'e}re de la Recherche et des Technologies, National Institutes of Health– Forgarty, Fondation pour la Recherche M{\'e}dicale and G{\'e}nopole-Lille (M.S.).",

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N1 - Funding Information: We thank M. Marti for preparation of the figures. Supported by the National Institute of Dental and Craniofacial Research (1 R01 DE014390-01A2), National Institutes of Health (K.A.B.) and the Centre National de la Recherche Scientifique, Ministére de la Recherche et des Technologies, National Institutes of Health– Forgarty, Fondation pour la Recherche Médicale and Génopole-Lille (M.S.).

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