TY - JOUR
T1 - The Neurobiology of Circadian Rhythms
AU - Sollars, Patricia J.
AU - Pickard, Gary E.
N1 - Funding Information:
This work was supported by NIH R01 NS077003 and R01 AI056346 .
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/12
Y1 - 2015/12
N2 - There is a growing recognition that the coordinated timing of behavioral, physiologic, and metabolic circadian rhythms is a requirement for a healthy body and mind. In mammals, the primary circadian oscillator is the hypothalamic suprachiasmatic nucleus (SCN), which is responsible for circadian coordination throughout the organism. Temporal homeostasis is recognized as a complex interplay between rhythmic clock gene expression in brain regions outside the SCN and in peripheral organs. Abnormalities in this intricate circadian orchestration may alter sleep patterns and contribute to the pathophysiology of affective disorders.
AB - There is a growing recognition that the coordinated timing of behavioral, physiologic, and metabolic circadian rhythms is a requirement for a healthy body and mind. In mammals, the primary circadian oscillator is the hypothalamic suprachiasmatic nucleus (SCN), which is responsible for circadian coordination throughout the organism. Temporal homeostasis is recognized as a complex interplay between rhythmic clock gene expression in brain regions outside the SCN and in peripheral organs. Abnormalities in this intricate circadian orchestration may alter sleep patterns and contribute to the pathophysiology of affective disorders.
KW - Biological rhythms
KW - Circadian oscillator
KW - Clock
KW - Intrinsically photosensitive retinal ganglion cells
KW - Suprachiasmatic nucleus
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U2 - 10.1016/j.psc.2015.07.003
DO - 10.1016/j.psc.2015.07.003
M3 - Review article
C2 - 26600101
AN - SCOPUS:84947496225
VL - 38
SP - 645
EP - 665
JO - Psychiatric Clinics of North America
JF - Psychiatric Clinics of North America
SN - 0193-953X
IS - 4
ER -