The Neurobiology of Circadian Rhythms

Patricia J. Sollars, Gary E. Pickard

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


There is a growing recognition that the coordinated timing of behavioral, physiologic, and metabolic circadian rhythms is a requirement for a healthy body and mind. In mammals, the primary circadian oscillator is the hypothalamic suprachiasmatic nucleus (SCN), which is responsible for circadian coordination throughout the organism. Temporal homeostasis is recognized as a complex interplay between rhythmic clock gene expression in brain regions outside the SCN and in peripheral organs. Abnormalities in this intricate circadian orchestration may alter sleep patterns and contribute to the pathophysiology of affective disorders.

Original languageEnglish (US)
Pages (from-to)645-665
Number of pages21
JournalPsychiatric Clinics of North America
Issue number4
StatePublished - Dec 2015


  • Biological rhythms
  • Circadian oscillator
  • Clock
  • Intrinsically photosensitive retinal ganglion cells
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Psychiatry and Mental health


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