The Neurobiology of Circadian Rhythms

Patricia J. Sollars; Gary E. Pickard

doi:10.1016/j.psc.2015.07.003

The Neurobiology of Circadian Rhythms

Patricia J. Sollars, Gary E. Pickard

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

There is a growing recognition that the coordinated timing of behavioral, physiologic, and metabolic circadian rhythms is a requirement for a healthy body and mind. In mammals, the primary circadian oscillator is the hypothalamic suprachiasmatic nucleus (SCN), which is responsible for circadian coordination throughout the organism. Temporal homeostasis is recognized as a complex interplay between rhythmic clock gene expression in brain regions outside the SCN and in peripheral organs. Abnormalities in this intricate circadian orchestration may alter sleep patterns and contribute to the pathophysiology of affective disorders.

Original language	English (US)
Pages (from-to)	645-665
Number of pages	21
Journal	Psychiatric Clinics of North America
Volume	38
Issue number	4
DOIs	https://doi.org/10.1016/j.psc.2015.07.003
State	Published - Dec 2015

Keywords

Biological rhythms
Circadian oscillator
Clock
Intrinsically photosensitive retinal ganglion cells
Suprachiasmatic nucleus

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1016/j.psc.2015.07.003

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title = "The Neurobiology of Circadian Rhythms",

abstract = "There is a growing recognition that the coordinated timing of behavioral, physiologic, and metabolic circadian rhythms is a requirement for a healthy body and mind. In mammals, the primary circadian oscillator is the hypothalamic suprachiasmatic nucleus (SCN), which is responsible for circadian coordination throughout the organism. Temporal homeostasis is recognized as a complex interplay between rhythmic clock gene expression in brain regions outside the SCN and in peripheral organs. Abnormalities in this intricate circadian orchestration may alter sleep patterns and contribute to the pathophysiology of affective disorders.",

keywords = "Biological rhythms, Circadian oscillator, Clock, Intrinsically photosensitive retinal ganglion cells, Suprachiasmatic nucleus",

author = "Sollars, {Patricia J.} and Pickard, {Gary E.}",

note = "Funding Information: This work was supported by NIH R01 NS077003 and R01 AI056346 . Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

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AU - Pickard, Gary E.

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AB - There is a growing recognition that the coordinated timing of behavioral, physiologic, and metabolic circadian rhythms is a requirement for a healthy body and mind. In mammals, the primary circadian oscillator is the hypothalamic suprachiasmatic nucleus (SCN), which is responsible for circadian coordination throughout the organism. Temporal homeostasis is recognized as a complex interplay between rhythmic clock gene expression in brain regions outside the SCN and in peripheral organs. Abnormalities in this intricate circadian orchestration may alter sleep patterns and contribute to the pathophysiology of affective disorders.

KW - Biological rhythms

KW - Circadian oscillator

KW - Clock

KW - Intrinsically photosensitive retinal ganglion cells

KW - Suprachiasmatic nucleus

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JO - Psychiatric Clinics of North America

JF - Psychiatric Clinics of North America

SN - 0193-953X

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The Neurobiology of Circadian Rhythms

Abstract

Keywords

ASJC Scopus subject areas

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