The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/ microglia-induced inflammation

Timothy K. Eitas, Wei Chun Chou, Haitao Wen, Denis Gris, Gregory R. Robbins, June Brickey, Yoshitaka Oyama, Jenny P.Y. Ting

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Background: The nucleotide-binding leucine-rich repeat (NLR) family of innate immune genes are important regulators of inflammatory responses in mammals. Results: The NLR gene, Nlrx1, suppresses neuroinflammation in vivo and inhibits microglial (Mg) activation. Conclusion: NLRX1 immunosuppressive function in Mg correlates with suppression of neuroinflammation during mouse models of Multiple Sclerosis (MS). Significance: NLR genes can have protective roles during neuroinflammation.

Original languageEnglish (US)
Pages (from-to)4173-4179
Number of pages7
JournalJournal of Biological Chemistry
Volume289
Issue number7
DOIs
StatePublished - Feb 14 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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