The ongoing quest for biomarkers in Ankylosing Spondylitis

Abhijeet Danve, James O'Dell

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Ankylosing Spondylitis poses significant challenges in terms of early diagnosis, assessment of disease activity, predicting response to the treatment and monitoring radiographic progression. With better understanding of underlying immunopathogenesis, effective targeted therapies are available which improve symptoms, quality of life and possibly slow the radiographic progression. There has been a growing interest in the discovery of biomarkers for defining various aspects of disease assessment and management in Ankylosing Spondylitis. The C-reactive protein and HLA-B27 are most commonly used biomarkers. This review describes many other newer biomarkers which have potential clinical applications in this chronic inflammatory disease.

Original languageEnglish (US)
Pages (from-to)826-834
Number of pages9
JournalInternational Journal of Rheumatic Diseases
Volume18
Issue number8
DOIs
StatePublished - Nov 1 2015

Keywords

  • Ankylosing spondylitis
  • Biomarker
  • Disease activity
  • Inflammatory bowel disease
  • Radiographic progression

ASJC Scopus subject areas

  • Rheumatology

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